Okeke Collins C, Ojo Angela, Ngige Onyinye, Amuchie Chukwunomso C, Obi Chibuike F, Charles Oyiyechukwu R, Ekeocha Ifunanya R, Konyeme Dumebi C, Idion Kris N, Balogun Favour O, Onwuchekwa Ijeoma, Ugo-Ihanetu Euodia A, Okafor Ginika S, Ogona Davida E, Okoye Chidera C, Igboanugo Somadila A
Anaesthesiology, Surgery Interest Group of Africa, Lagos, NGA.
Internal Medicine, University of Port Harcourt, Rivers State, NGA.
Cureus. 2025 Mar 27;17(3):e81277. doi: 10.7759/cureus.81277. eCollection 2025 Mar.
Social isolation and loneliness seriously impact the physical and mental quality of health and longevity. Social isolation and loneliness are important yet neglected social determinants for people of all ages. Cardiovascular diseases (CVD) are among the leading causes of death globally, and loneliness has been linked to worsening outcomes of CVD. This review aims to evaluate the impact of loneliness/social/self-isolation among adults living with any cardiovascular disease. A systematic search was done from inception to 23rd January 2025 on PubMed and Google Scholar, and 4,198 articles were synthesized; these articles were screened for duplication, and the duplicate articles were removed. A total of 3,606 articles underwent title and abstract screening, and 3,505 articles were removed following the predefined eligibility criteria. One hundred and one articles underwent full-text screening, and only 13 articles were included for qualitative analysis. We included adults aged 18 and above living alone/socially isolated with any cardiovascular disease. This systematic review analyzed 13 studies across eight countries, encompassing 63,978 participants, of whom 12,110 were identified as living alone or socially isolated, 7,264 male and 3,745 female participants; one study included only male participants, while two studies didn't mention the number of male and female participants. The findings provide compelling evidence that loneliness is associated with adverse cardiovascular disease (CVD) outcomes, including increased mortality, recurrent cardiovascular events, and higher hospitalization rates. Addressing loneliness and social isolation should be a priority in cardiovascular disease prevention and management. Integrating social interventions could significantly improve the prognosis of individuals living with CVD, ultimately reducing morbidity and mortality rates in this vulnerable population.
社会孤立和孤独严重影响身心健康及寿命质量。社会孤立和孤独是所有年龄段人群重要但被忽视的社会决定因素。心血管疾病（CVD）是全球主要死因之一，孤独与心血管疾病的不良预后相关。本综述旨在评估孤独/社交/自我隔离对患有任何心血管疾病的成年人的影响。从创刊至2025年1月23日在PubMed和谷歌学术上进行了系统检索，共综合了4198篇文章；对这些文章进行了重复筛选，去除了重复文章。共有3606篇文章进行了标题和摘要筛选，根据预先设定的纳入标准，排除了3505篇文章。101篇文章进行了全文筛选，仅13篇文章纳入定性分析。我们纳入了年龄在18岁及以上、患有任何心血管疾病且独居/社交孤立的成年人。本系统综述分析了来自八个国家的13项研究，涵盖63978名参与者，其中12110人被确定为独居或社交孤立，男性参与者7264人，女性参与者3745人；一项研究仅纳入男性参与者，两项研究未提及男女参与者数量。研究结果提供了有力证据，表明孤独与心血管疾病（CVD）的不良预后相关，包括死亡率增加、心血管事件复发和住院率升高。解决孤独和社会孤立问题应成为心血管疾病预防和管理的优先事项。整合社会干预措施可显著改善心血管疾病患者的预后，最终降低这一弱势群体的发病率和死亡率。
