Inoperable Endometrial Carcinoma Treated With External Beam Radiation and a Stereotactic Body Radiation Therapy Boost.

A significant comorbidity of endometrial cancer is severe obesity with a Body Mass Index (BMI) of greater than 40, which can dramatically limit treatment options such as surgery or brachytherapy. Alternative treatment options need to be investigated, and in this case report, we examine a female with severe obesity and a significantly enlarged uterus who was ineligible for surgery or intracavitary brachytherapy (ICBT). She subsequently underwent treatment with external beam radiation therapy (EBRT) alone to the pelvis, followed by a stereotactic radiation therapy boost (SBRT) to the uterus. Following treatment, her uterine bleeding subsided, and she is currently without evidence of disease.