Moshref Rana, Elashaal Abdurrahim
Neurosurgery, London Health Sciences Centre, London, CAN.
Neurosurgery, Windsor Regional Hospital - Ouellette Campus, Windsor, CAN.
Cureus. 2025 Mar 26;17(3):e81231. doi: 10.7759/cureus.81231. eCollection 2025 Mar.
Glioblastoma is the most aggressive and common primary brain tumor. Diagnosis is based on imaging and is confirmed through a brain biopsy. Multimodal treatment, including gross total resection, radiotherapy, and chemotherapy, is typically required. We report a case of a 79-year-old woman, a former smoker, who presented with a headache and generalized weakness and was found to have multiple brain lesions. The patient was diagnosed with glioblastoma and underwent partial resection. Multiple glioblastomas are a rare presentation and can be multicentric or multifocal. Patients with this presentation typically exhibit symptoms of high intracranial pressure. Glioblastomas have a poor prognosis despite multidisciplinary management. Glioblastoma should be considered a differential diagnosis for patients with multiple brain lesions.
胶质母细胞瘤是最具侵袭性且常见的原发性脑肿瘤。诊断基于影像学检查，并通过脑活检得以确诊。通常需要多模式治疗，包括肿瘤全切、放疗和化疗。我们报告一例79岁女性病例，该患者既往吸烟，出现头痛和全身乏力症状，经检查发现有多处脑病变。患者被诊断为胶质母细胞瘤并接受了部分切除术。多发性胶质母细胞瘤是一种罕见的表现形式，可为多中心性或多灶性。有此表现的患者通常会出现颅内压升高的症状。尽管采取了多学科管理，但胶质母细胞瘤的预后较差。对于有多处脑病变的患者，应将胶质母细胞瘤列为鉴别诊断之一。
