文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

对醋酸诱导的炎症性肠病的保护作用是通过调节抗氧化和炎症介质来介导的。

Protective effects of against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators.

作者信息

Javaid Faraza, Jabeen Qaiser

机构信息

Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.

College of Pharmacy, Quaid-e-Azam Educational Complex, Sahiwal, Pakistan.

出版信息

Avicenna J Phytomed. 2025 Jan-Feb;15(2):964-980. doi: 10.22038/AJP.2024.24977.

DOI:10.22038/AJP.2024.24977
PMID:40292264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12033016/
Abstract

OBJECTIVE: The plant Burm. f., belonging to the family Fabaceae, is locally known as Hathio, Jantar and Neel. This plant is commonly found in deserted habitat and used traditionally to treat inflammatory and gastric disorders. The current study was designed to evaluate the phytochemical profile, toxicity and intestinal anti-inflammatory effects of the whole plant crude extract against acetic acid-induced inflammatory bowel disease (IBD) in mice. MATERIALS AND METHODS: To study the phytochemical composition, preliminary phytochemical analysis along with HPLC and LCMS of the crude extract of (Ia.Cr) was performed. For the evaluation of intestinal anti-inflammatory activity, animals were divided into five groups (normal control, intoxicated, standard and two treatment groups) of six animals each and ulcerative colitis (UC) was induced by intrarectal administration of acetic acid (200 µl of 7.5%) and extent of damage caused by ulcerative colitis was measured by colonic mucosal damage index, disease activity index, and hematological and histological changes. Lipo-peroxide activity by malondialdehyde (MDA) and antioxidant enzyme glutathione peroxidase (GPX-1), catalase (CAT) and superoxide dismutase (SOD) levels were determined in colon tissues. Pro-inflammatory cytokines (IL-1, IL-6 and TNF-α) were quantified by ELISA immunoassay. RESULTS: Pre-treatment with Ia.Cr significantly amended macroscopic damage, and hematological and histopathological alterations. Ia.Cr decreased oxidative parameters such as MDA and increased antioxidant activities of GPX-1, CAT and SOD. Ia.Cr also decreased the levels of pro-inflammatory biomarkers significantly. CONCLUSION: Results of this study indicated that Ia.Cr protected mice against acetic acid-induced inflammatory bowel disease by decreasing endogenous inflammatory biomarkers and oxidative damages.

摘要

目的：植物[具体植物名称未给出]，属于豆科，当地称为哈蒂奥、詹塔尔和尼尔。这种植物常见于荒芜的栖息地，传统上用于治疗炎症和胃部疾病。本研究旨在评估全株粗提物的植物化学特征、毒性以及对小鼠醋酸诱导的炎症性肠病（IBD）的肠道抗炎作用。 材料与方法：为研究植物化学组成，对[具体植物名称未给出]粗提物（Ia.Cr）进行了初步植物化学分析以及高效液相色谱（HPLC）和液相色谱 - 质谱联用（LCMS）分析。为评估肠道抗炎活性，将动物分为五组（正常对照组、中毒组、标准组和两个治疗组），每组六只动物，通过直肠内注射醋酸（200微升7.5%）诱导溃疡性结肠炎（UC），并通过结肠黏膜损伤指数、疾病活动指数以及血液学和组织学变化来测量溃疡性结肠炎造成的损伤程度。测定结肠组织中丙二醛（MDA）的脂过氧化活性以及抗氧化酶谷胱甘肽过氧化物酶（GPX - 1）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的水平。通过酶联免疫吸附测定（ELISA）免疫分析法对促炎细胞因子（IL - 1、IL - 6和TNF - α）进行定量分析。 结果：用Ia.Cr预处理显著改善了宏观损伤以及血液学和组织病理学改变。Ia.Cr降低了氧化参数如MDA，并提高了GPX - 1、CAT和SOD的抗氧化活性。Ia.Cr还显著降低了促炎生物标志物的水平。 结论：本研究结果表明，Ia.Cr通过降低内源性炎症生物标志物和氧化损伤来保护小鼠免受醋酸诱导的炎症性肠病的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/e97cedae0955/AJP-15-964-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/5acea4a9062b/AJP-15-964-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/9fb4353ef75b/AJP-15-964-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/8638949d88f0/AJP-15-964-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/a7ecd79a916e/AJP-15-964-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/c2ccd8174e3c/AJP-15-964-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/2f7e7eb1fe65/AJP-15-964-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/4ac68204adbd/AJP-15-964-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/0329b62d5cb0/AJP-15-964-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/e97cedae0955/AJP-15-964-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/5acea4a9062b/AJP-15-964-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/9fb4353ef75b/AJP-15-964-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/8638949d88f0/AJP-15-964-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/a7ecd79a916e/AJP-15-964-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/c2ccd8174e3c/AJP-15-964-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/2f7e7eb1fe65/AJP-15-964-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/4ac68204adbd/AJP-15-964-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/0329b62d5cb0/AJP-15-964-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76d7/12033016/e97cedae0955/AJP-15-964-g009.jpg

相似文献

[1]
Protective effects of against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators.

Avicenna J Phytomed. 2025

[2]
Gisekia pharnaceoides Restores Colonic Mucosal Homeostasis by Regulating Antioxidant Enzyme System and Cytokines Signaling in Ulcerative Colitis Mice Model.

Endocr Metab Immune Disord Drug Targets. 2022

[3]
Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f.

J Ethnopharmacol. 2020-9-15

[4]
Flaxseed extract exhibits mucosal protective effect in acetic acid induced colitis in mice by modulating cytokines, antioxidant and antiinflammatory mechanisms.

Int Immunopharmacol. 2016-9

[5]
Piper umbellatum L. (Piperaceae): Phytochemical profiles of the hydroethanolic leaf extract and intestinal anti-inflammatory mechanisms on 2,4,6 trinitrobenzene sulfonic acid induced ulcerative colitis in rats.

J Ethnopharmacol. 2020-5-23

[6]
Anti-ulcerative colitis effects of chemically characterized extracts from C in acetic acid-induced ulcerative colitis.

Front Chem. 2024-2-27

[7]
Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats.

BMC Complement Altern Med. 2014-2-10

[8]
Protective effect of Sesbania grandiflora on acetic acid induced ulcerative colitis in mice by inhibition of TNF-α and IL-6.

J Ethnopharmacol. 2018-3-10

[9]
Copaifera malmei Harms leaves infusion attenuates TNBS-ulcerative colitis through modulation of cytokines, oxidative stress and mucus in experimental rats.

J Ethnopharmacol. 2021-3-1

[10]
Lycopodium Mitigates Oxidative Stress and Inflammation in the Colonic Mucosa of Acetic Acid-Induced Colitis in Rats.

Molecules. 2022-4-26

本文引用的文献

[1]
Kaempferide improves oxidative stress and inflammation by inhibiting the TLR4/IκBα/NF-κB pathway in obese mice.

Iran J Basic Med Sci. 2021-4

[2]
Pharmacological investigation of activities pertaining to modulation of gastrointestinal, respiratory and cardiovascular parameters by Indigofera argentea in experimental models.

Pak J Pharm Sci. 2020-9

[3]
Effects of Aqueous and Methanolic Extracts of Stem Bark of De Wild. (Apocynaceae) on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Wistar Rats.

Evid Based Complement Alternat Med. 2020-5-30

[4]
Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f.

J Ethnopharmacol. 2020-9-15

[5]
Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease.

Nat Commun. 2020-3-23

[6]
Grape peel powder attenuates the inflammatory and oxidative response of experimental colitis in rats by modulating the NF-κB pathway and activity of antioxidant enzymes.

Nutr Res. 2020-4

[7]
Piper umbellatum L. (Piperaceae): Phytochemical profiles of the hydroethanolic leaf extract and intestinal anti-inflammatory mechanisms on 2,4,6 trinitrobenzene sulfonic acid induced ulcerative colitis in rats.

J Ethnopharmacol. 2020-5-23

[8]
Targeting NF-κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines.

Chin Med. 2020-2-10

[9]
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.

Autophagy. 2019-7-9

[10]
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-B/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.

Oxid Med Cell Longev. 2019-4-28

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索