Zhang Lihui, Liu Sutong, Zhao Qing, Liu Xiaoyan, Zhang Qiang, Liu Minghao, Zhao Wenxiao
The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Zhengzhou, Henan, China.
Front Immunol. 2025 Apr 11;16:1535362. doi: 10.3389/fimmu.2025.1535362. eCollection 2025.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and is closely associated with metabolic abnormalities. The causes of NAFLD are exceedingly complicated, and it is known that a variety of signaling pathways, endoplasmic reticulum stress, and mitochondrial dysfunction play a role in the pathogenesis of NAFLD. Recent studies have shown that ubiquitination and deubiquitination are involved in the regulation of the NAFLD pathophysiology. Protein ubiquitination is a dynamic and diverse post-translational alteration that affects various cellular biological processes. Numerous disorders, including NAFLD, exhibit imbalances in ubiquitination and deubiquitination. To highlight the significance of this post-translational modification in the pathogenesis of NAFLD and to aid in the development of new therapeutic approaches for the disease, we will discuss the role of enzymes involved in the processes of ubiquitination and deubiquitination, specifically E3 ubiquitin ligases and deubiquitinating enzymes that are important in the regulation of NAFLD.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病之一，与代谢异常密切相关。NAFLD的病因极其复杂，已知多种信号通路、内质网应激和线粒体功能障碍在NAFLD的发病机制中起作用。最近的研究表明，泛素化和去泛素化参与了NAFLD病理生理学的调节。蛋白质泛素化是一种动态且多样的翻译后修饰，影响各种细胞生物学过程。包括NAFLD在内的许多疾病都表现出泛素化和去泛素化的失衡。为了突出这种翻译后修饰在NAFLD发病机制中的重要性，并有助于开发该疾病的新治疗方法，我们将讨论参与泛素化和去泛素化过程的酶的作用，特别是在NAFLD调节中起重要作用的E3泛素连接酶和去泛素化酶。
