Chen Juan, Zhou Fangfang, Shen Jian, Pang Jun, Chu Hanqing
Department of Nephrology, The Affiliated YangMing Hospital of NingBo University (Yuyao People's Hospital), Ningbo, Zhejiang, China.
Department of Nephrology, Ningbo No.2 Hospital, Ningbo, Zhejiang, China.
Front Immunol. 2025 Apr 11;16:1551094. doi: 10.3389/fimmu.2025.1551094. eCollection 2025.
Primary Sjögren's syndrome (pSS) is an autoimmune disease that often affects the exocrine glands. However, pSS can also affect the kidneys, most commonly involving the kidney interstitium. Recent studies have demonstrated that some membranous nephropathy (MN) cases are associated with Sjögren's syndrome. However, unified recommendations for selecting immunosuppressive agents for treating MN associated with pSS are currently lacking. In the case reported herein, a patient with MN associated with pSS experienced improvement following methylprednisolone and telitacicept treatment.
原发性干燥综合征（pSS）是一种常累及外分泌腺的自身免疫性疾病。然而，pSS也可累及肾脏，最常见的是累及肾间质。最近的研究表明，一些膜性肾病（MN）病例与干燥综合征有关。然而，目前缺乏针对治疗与pSS相关的MN选择免疫抑制剂的统一建议。在本文报道的病例中，一名患有与pSS相关的MN的患者在接受甲泼尼龙和泰吉华治疗后病情有所改善。
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