Tripathy Rachana, Kumar Lalit, Kural Sukhad, Thakur Anuja, Trivedi Sameer, Sankhwar Satya Narayan
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Indian J Urol. 2025 Apr-Jun;41(2):98-103. doi: 10.4103/iju.iju_442_24. Epub 2025 Apr 1.
MicroRNAs, small noncoding RNA molecules, are critical in modulating gene expression and contribute substantially to the initiation and progression of urinary bladder cancer (UBCa), a major malignancy affecting people globally. UBCa is known for its high recurrence rates and significant heterogeneity. The stability of miRNAs in body fluids such as urine and blood are excellent potential noninvasive markers for early detection, monitoring treatment progress, and predicting outcomes of patients with UBCa. In addition, miRNAs could also improve the effectiveness of immunotherapy and support the development of personalized treatment strategies. Despite their significant potential, challenges such as variability in the expression of miRNAs and shortcomings in their delivery systems must be carefully addressed. This strength, weakness, opportunity, and threat (SWOT) analysis highlights the crucial role of miRNAs in UBCa and explores their potential in advancing precision oncology.
微小RNA（MicroRNAs）是一类小的非编码RNA分子，在调节基因表达中起关键作用，并在膀胱癌（UBCa）的发生和发展中起重要作用。膀胱癌是一种影响全球人群的主要恶性肿瘤。膀胱癌以其高复发率和显著的异质性而闻名。尿液和血液等体液中miRNA的稳定性是早期检测、监测治疗进展和预测膀胱癌患者预后的优秀潜在非侵入性标志物。此外，miRNA还可以提高免疫治疗的有效性，并支持个性化治疗策略的发展。尽管它们具有巨大潜力，但必须谨慎应对诸如miRNA表达变异性及其递送系统缺陷等挑战。这种优势、劣势、机会和威胁（SWOT）分析突出了miRNA在膀胱癌中的关键作用，并探讨了它们在推进精准肿瘤学方面的潜力。
