Zhu Qi, Yang Qing, Shen Ling, Xu Meifeng, Liu Min
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA.
Nutrients. 2025 Mar 15;17(6):1034. doi: 10.3390/nu17061034.
Cannabidiol (CBD) exerts diverse metabolic effects, yet its influence on intestinal lipid metabolism remains unclear. In this study, we investigated whether short-term (one-week) CBD treatment affects lipid absorption and transport through the lymphatic system using a validated lymph fistula model. CBD treatment significantly enhanced the transport of radiolabeled triglycerides through the lymphatic system. This effect appeared specific, as CBD did not substantially alter cholesterol output in the lymph. Chemical assays indicated that CBD treatment did not significantly alter total triglycerides, cholesterol, phospholipids, or non-esterified fatty acid levels in the lymph. However, it significantly enhanced the lymphatic output of apolipoprotein A4 (ApoA4) and apolipoprotein A1 (ApoA1). Additionally, gene expression analysis revealed a downregulation of vascular endothelial growth factor receptor 1 (Flt1) in the small intestine, leading to increased lymphatic lacteal permeability and altered lipid transport dynamics. These findings indicate that short-term CBD treatment modulates lymphatic lipid composition and apolipoprotein secretion by regulating lymphatic lacteal function, thereby influencing lipid transport and metabolism. This study provides novel insights into CBD's role in facilitating TG-rich lipoprotein transport via the lymphatic system, highlighting its potential therapeutic applications in lipid-related disorders.
大麻二酚（CBD）具有多种代谢作用，但其对肠道脂质代谢的影响尚不清楚。在本研究中，我们使用经过验证的淋巴瘘模型，研究了短期（一周）CBD治疗是否会影响脂质通过淋巴系统的吸收和运输。CBD治疗显著增强了放射性标记甘油三酯通过淋巴系统的运输。这种作用似乎具有特异性，因为CBD并未显著改变淋巴中胆固醇的输出。化学分析表明，CBD治疗并未显著改变淋巴中总甘油三酯、胆固醇、磷脂或非酯化脂肪酸的水平。然而，它显著增强了载脂蛋白A4（ApoA4）和载脂蛋白A1（ApoA1）的淋巴输出。此外，基因表达分析显示小肠中血管内皮生长因子受体1（Flt1）下调，导致淋巴乳糜管通透性增加和脂质运输动力学改变。这些发现表明，短期CBD治疗通过调节淋巴乳糜管功能来调节淋巴脂质组成和载脂蛋白分泌，从而影响脂质运输和代谢。本研究为CBD在促进富含甘油三酯的脂蛋白通过淋巴系统运输中的作用提供了新的见解，突出了其在脂质相关疾病中的潜在治疗应用。
