Limani Rinë, Kondirolli Labinota, Blakaj Gashi Brikenë, Ulamec Monika, Krušlin Božo
Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Institute of Anatomical Pathology, University Clinical Center of Kosovo, Prishtina, Kosovo.
Future Sci OA. 2025 Dec;11(1):2494972. doi: 10.1080/20565623.2025.2494972. Epub 2025 Apr 28.
We analyzed immunoexpression of Dysadherin, E-cadherin and ß-catenin proteins in prostate.
53 radical prostatectomy specimens were included. Dysadherin, E-cadherin and ß-catenin were evaluated in prostatic adenocarcinoma and in adjacent non-tumorous tissue, and correlated with clinicomorphological features in prostatic adenocarcinoma.
We report cytoplasmic/membraneous and nuclear staining for Dysadherin in prostatic tissue. Cytoplasmic/membraneous expression was stronger in prostatic adenocarcinoma when compared to adjacent non-tumorous prostatic tissue (p < 0.001).
Dysadherin positively correlated with T status (rho = 0.326, P = 0.017) and Grade Group (rho = 0.278, P = 0.044). We report no correlation with recurrence, surgical margins status, sPSA and N status. E-cadherin was negatively correlated with recurrence (rho = -0.297, P = 0.031), T status (rho = -0.430, P = 0.001), Grade Group (rho = -0.558, P < 0.001) and positive surgical margins (rho = -0.404, P = 0.003). ß-catenin negatively correlated with Grade Group (rho = -0.557, P < 0,001). No correlation was observed between Dysadherin and E-cadherin and Dysadherin and ß-catenin expression.
Our results suggest a potential role for Dysadherin in tumor progression. No significant correlation between Dysadherin and E-cadherin or ß-catenin indicates potential independence of Dysadherin in its regulatory role in prostatic adenocarcinoma.
我们分析了前列腺中去黏附素、E-钙黏蛋白和β-连环蛋白的免疫表达情况。
纳入53例前列腺癌根治术标本。对前列腺腺癌及相邻非肿瘤组织中的去黏附素、E-钙黏蛋白和β-连环蛋白进行评估，并与前列腺腺癌的临床形态学特征进行关联分析。
我们报道了前列腺组织中去黏附素的胞质/膜性及核染色情况。与相邻非肿瘤性前列腺组织相比，前列腺腺癌中的胞质/膜性表达更强（p < 0.001）。
去黏附素与T分期呈正相关（rho = 0.326，P = 0.017），与分级组呈正相关（rho = 0.278，P = 0.044）。我们报道其与复发、手术切缘状态、血清前列腺特异抗原（sPSA）及N分期无相关性。E-钙黏蛋白与复发呈负相关（rho = -0.297，P = 0.031），与T分期呈负相关（rho = -0.430，P = 0.001），与分级组呈负相关（rho = -0.558，P < 0.001），与手术切缘阳性呈负相关（rho = -0.404，P = 0.003）。β-连环蛋白与分级组呈负相关（rho = -0.557，P < 0.001）。未观察到去黏附素与E-钙黏蛋白及去黏附素与β-连环蛋白表达之间的相关性。
我们的结果提示去黏附素在肿瘤进展中可能发挥作用。去黏附素与E-钙黏蛋白或β-连环蛋白之间无显著相关性，表明去黏附素在前列腺腺癌中的调节作用可能具有独立性。
