Analyzing the patterns of adverse drug reactions due to anti-infectives from large-scale nationwide database in Thailand.

BACKGROUND

Adverse drug reactions (ADRs), which can occur in any drug class and are one of the leading causes of morbidity and hospitalization around the world, remain a public health concern. This study aimed to explore the distribution and patterns of anti-infective-induced ADRs in Thailand.

RESEARCH DESIGN AND METHODS

The national database of anti-infective-induced ADRs from January 2012 to December 2021 in the 77 provinces of Thailand. After the pre-processing, frequencies and percentages were used to examine the distribution of the ADRs. The chi-square test was used for measuring association for anti-infective-induced ADRs.

RESULTS

A total of 82,333 anti-infective-induced ADR reports were recorded from 2012-2021 in the 77 provinces of Thailand. The most commonly reported ADRs were in Central Thailand (29.0%), followed by the Northeast (25.9%). Most of the patients were females aged 20-39. Antibiotics categorized by chemical structure, cephalosporin (28.0%) and penicillin (23.4%), were the most common anti-infective drug-induced ADRs. Dose frequency and ADR onset were statistically associated with therapeutic drug class, anti-infective group, and disease (p-value < 0.05).

CONCLUSIONS

The results of this study will enable healthcare professionals to prioritize groups and policymakers to make effective ADR prevention policies to reduce the risk and improve patient safety.