预靶向：连接放射性药物探针的两个世界。
Pretargeting: Bridging the Two Worlds of Radiopharmaceutical Probes.
作者信息
Mori Yuriko, Cardinale Jens, Giesel Frederik L
机构信息
Department of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Institute for Radiation Sciences, The University of Osaka, Osaka, Japan.
出版信息
Clin Cancer Res. 2025 Jul 1;31(13):2547-2549. doi: 10.1158/1078-0432.CCR-25-0568.
The human trophoblast cell-surface antigen 2 is expressed in a variety of malignant diseases. Using pretargeting methodology, a novel antibody against trophoblast cell-surface antigen 2 was radiolabeled and evaluated in a preclinical setting. This showed promising characteristics, lending itself as a potential basis for further clinical trials as an imaging agent and a potential theranostic. See related article by Pratt et al., p. 2719.
人滋养层细胞表面抗原2在多种恶性疾病中表达。采用预靶向方法，一种针对滋养层细胞表面抗原2的新型抗体被放射性标记，并在临床前环境中进行评估。结果显示出有前景的特性，使其有望作为成像剂及潜在的诊疗试剂用于进一步的临床试验。见普拉特等人的相关文章，第2719页。
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