Maloney Alan C, McDonald Matthew J, Petroski Gregory F, Kanaley Jill A
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.
Department of Bioinformatics, Biostatistics, & Medical Epidemiology, University of Missouri, Columbia, MO, USA.
Appl Physiol Nutr Metab. 2025 Jan 1;50:1-10. doi: 10.1139/apnm-2024-0535.
Sleep restriction (SR) impairs postprandial glycemia following a high-glucose challenge and exercise improves it, but their combined impact on postprandial lipemia in response to a high-fat challenge remains unknown. This project investigated whether one night of SR impairs morning postprandial lipemia and if prior evening exercise influences the response. We hypothesized SR would induce an exaggerated postprandial lipemic response to a high-fat morning challenge and that prior evening exercise would fully or partially ameliorate these impairments. In 10 sedentary individuals with overweight or obesity (females: 4, age: 28.1 ± 3.8 years, body mass index: 30.4 ± 2.2 kg/m), we compared the effects of one night of SR (4 h) to normal sleep (8 h), with and without prior moderate-intensity aerobic exercise (45 min, 65% VOmax), on postprandial lipemia and satiety following a standardized high-fat morning challenge (4 h). Spline regression was used to compare differences in the time course of the blood-based outcomes between exercise and sleep conditions. No significant differences were observed in fasting or 2 h concentrations of glucose, insulin, non-esterified fatty acids, or triglyceride, areas under the curves, indexes of metabolism, or satiety between conditions. However, exercise had an interaction between the spline term and exercise and sleep conditions ( < 0.001) for glucose, insulin, non-esterified fatty acids, and triglycerides during the high-fat challenge. The findings indicate that one night of SR has minimal effects on morning postprandial lipemia, irrespective of previous aerobic exercise. Notably, exercise reduced triglyceride concentrations in the latter half of the testing period, although this effect was abolished during SR conditions. Clinical trial #: NCT05713370.
睡眠限制（SR）会损害高糖挑战后的餐后血糖水平，而运动可改善这一情况，但它们对高脂挑战后餐后血脂的综合影响仍不清楚。本项目研究了一晚的睡眠限制是否会损害早晨的餐后血脂，以及前一晚的运动是否会影响这种反应。我们假设睡眠限制会导致对高脂早晨挑战的餐后血脂反应过度，而前一晚的运动将完全或部分改善这些损害。在10名超重或肥胖的久坐不动个体（女性：4名，年龄：28.1±3.8岁，体重指数：30.4±2.2kg/m²）中，我们比较了一晚的睡眠限制（4小时）与正常睡眠（8小时），在有和没有前一晚中等强度有氧运动（45分钟，65%最大摄氧量）的情况下，对标准化高脂早晨挑战（4小时）后餐后血脂和饱腹感的影响。使用样条回归来比较运动和睡眠条件下基于血液的结果随时间变化过程的差异。在空腹或2小时的葡萄糖、胰岛素、非酯化脂肪酸或甘油三酯浓度、曲线下面积、代谢指标或饱腹感方面，各条件之间未观察到显著差异。然而，在高脂挑战期间，运动在葡萄糖、胰岛素、非酯化脂肪酸和甘油三酯的样条项与运动和睡眠条件之间存在交互作用（P<0.001）。研究结果表明，一晚的睡眠限制对早晨餐后血脂的影响最小，无论之前是否进行有氧运动。值得注意的是，运动在测试期后半段降低了甘油三酯浓度，尽管在睡眠限制条件下这种效果消失了。临床试验编号：NCT05713370。
