阴道镜改变在吸烟者中更为常见，且出现年龄更小。
Colposcopic Alterations Are More Frequent in Smokers and Appear at a Younger Age.
作者信息
Mora Diego Erasun, Del Campo Ana Vázquez, DE Castro Momioto Alazne, Solano Alberto Muñoz, Schneider Jose
机构信息
Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain;
Hospital Universitario Marqués de Valdecilla/IDIVAL, Santander, Spain.
出版信息
In Vivo. 2025 May-Jun;39(3):1453-1457. doi: 10.21873/invivo.13946.
BACKGROUND/AIM: Tobacco use is a recognized cofactor risk for cervical cancer induced by high-risk Human Papilloma Virus (HR-HPV). This study aimed to evaluate the specific influence of tobacco use on colposcopic examination results in women infected by HR-HPV.
PATIENTS AND METHODS
HR-HPV-positive women undergoing a loop electrosurgical excision procedure (LLETZ) after colposcopic examination were considered for this study. A total of 819 patients from a regional screening program were included, of whom 320 were smokers and 499 non-smokers.
RESULTS
Smokers were significantly younger (41.1 43.8, <0.01), more frequently exhibited grade II colposcopic changes (63.9% 53.3%, <0.05), had worse histopathological outcomes (CIN2+: 75.7% 67.9%, <0.05; CIN3+: 51.4% 44.0%, <0.05), and higher rates of affected surgical margins, with borderline significance (22.6% 17.8%, =0.055). While no significant differences in viral clearance were observed at six months, smokers showed a trend toward worse outcomes at two years (=0.07).
CONCLUSION
Smoking in any amount is associated with worse colposcopic and histopathological findings, and this occurs at younger ages.
背景/目的：吸烟是高危型人乳头瘤病毒（HR-HPV）诱发宫颈癌的一个公认的协同风险因素。本研究旨在评估吸烟对HR-HPV感染女性阴道镜检查结果的具体影响。
患者与方法
本研究纳入了在阴道镜检查后接受环形电切术（LLETZ）的HR-HPV阳性女性。共纳入了来自一项区域筛查项目的819例患者，其中320例为吸烟者，499例为非吸烟者。
结果
吸烟者明显更年轻（41.1对43.8，P<0.01），更频繁地出现二级阴道镜改变（63.9%对53.3%，P<0.05），组织病理学结果更差（CIN2+：75.7%对67.9%，P<0.05；CIN3+：51.4%对44.0%，P<0.05），手术切缘受影响的比例更高，具有临界显著性（22.6%对17.8%，P=0.055）。虽然在6个月时未观察到病毒清除率的显著差异，但吸烟者在2年时显示出预后较差的趋势（P=0.07）。
结论
任何量的吸烟都与更差的阴道镜和组织病理学结果相关，且这种情况在更年轻的年龄出现。
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