Li Li, Xiao Yubo, Wen Wenwei, Liu Qi, Wei Le, Liu Pinyue, Li Ming
Department of Histology and Embryology, Hunan University of Medicine, Huaihua, China.
School of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, China.
Medicine (Baltimore). 2025 Apr 25;104(17):e42228. doi: 10.1097/MD.0000000000042228.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among fertile women, which is influenced by genetics and environment. A recent study revealed that PCOS patients were in a chronic inflammatory state, and they had abnormally activated macrophages. This paper introduces the relationship between PCOS and macrophages. The forkhead box protein O1 (FOXO-1), migration inhibitory factor, sympathetic conservation disorder, and vitamin D are believed to influence macrophages in PCOS. There is evidence that PCOS-associated abnormalities are associated with macrophages, including insulin resistance, obesity, hyperandrogenism (HA), hyperhomocysteinemia (HHcy), cardiometabolic disorder and gut microbiota dysbiosis. This review summarizes the research status of macrophages in PCOS. Macrophages might be a potential PCOS treatment candidate.
多囊卵巢综合征（PCOS）是育龄女性中常见的一种内分泌紊乱疾病，受遗传和环境因素影响。最近一项研究表明，PCOS患者处于慢性炎症状态，且其巨噬细胞异常激活。本文介绍了PCOS与巨噬细胞之间的关系。据信，叉头框蛋白O1（FOXO-1）、迁移抑制因子、交感神经保护障碍和维生素D会影响PCOS中的巨噬细胞。有证据表明，PCOS相关异常与巨噬细胞有关，包括胰岛素抵抗、肥胖、高雄激素血症（HA）、高同型半胱氨酸血症（HHcy）、心脏代谢紊乱和肠道微生物群失调。本综述总结了巨噬细胞在PCOS中的研究现状。巨噬细胞可能是PCOS治疗的一个潜在候选靶点。
