使用司库奇尤单抗成功治疗合并慢性乙型肝炎的泛发性脓疱型银屑病：一例报告
Successful treatment of generalized pustular psoriasis with chronic hepatitis B using spesolimab: A case report.
作者信息
Ming Ruiyuan, Zhang Lei, Xiong Xincai
机构信息
Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
出版信息
Medicine (Baltimore). 2025 Apr 25;104(17):e41979. doi: 10.1097/MD.0000000000041979.
RATIONALE
Generalized pustular psoriasis (GPP) is a severe form of pustular psoriasis, which can endanger the patient life. However, the conventional treatment for GPP presents several limitations.
PATIENT CONCERNS
In this report, we present a 54-year-old male patient with GPP and chronic hepatitis B. The use of glucocorticoids and acitretin for GPP caused liver injury in our case.
DIAGNOSES
The patient was diagnosed with GPP with chronic hepatitis B.
INTERVENTIONS
The patient accepted traditional therapy, including glucocorticoids and acitretin. The use of glucocorticoids and acitretin for GPP caused liver injury in our case. Therefore, acitretin was discontinued (but not the glucocorticoid). After excluding contraindications, the patient was administered a single dose of spesolimab (900 mg).
OUTCOMES
The rash resolved within 48 hours after the patient was administered a single dose of spesolimab (900 mg).
LESSONS
Our study shows that spesolimab could be employed as a safe and effective therapeutic option for patients with GPP and other underlying conditions.
原理
泛发性脓疱型银屑病（GPP）是脓疱型银屑病的一种严重形式，可危及患者生命。然而，GPP的传统治疗存在一些局限性。
患者关注
在本报告中，我们介绍了一名54岁的男性GPP患者，同时患有慢性乙型肝炎。在我们的病例中，使用糖皮质激素和阿维A治疗GPP导致了肝损伤。
诊断
该患者被诊断为患有慢性乙型肝炎的GPP。
干预措施
患者接受了包括糖皮质激素和阿维A在内的传统治疗。在我们的病例中，使用糖皮质激素和阿维A治疗GPP导致了肝损伤。因此，停用了阿维A（但未停用糖皮质激素）。在排除禁忌症后，给患者单次注射司库奇尤单抗（900mg）。
结果
患者单次注射司库奇尤单抗（900mg）后48小时内皮疹消退。
经验教训
我们的研究表明，司库奇尤单抗可作为GPP及其他基础疾病患者的一种安全有效的治疗选择。
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