孕妇胎盘异常附着的血清标志物
Serum Markers of Abnormal Placental Attachment in Pregnant Women.
作者信息
Artemyeva K A, Kulikov I A, Nizyaeva N V, Stepanova I I, Tikhonova N B, Mikhaleva L M
机构信息
Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia.
Vidnovsky Perinatal Center, Vidnoe, Russia.
出版信息
Bull Exp Biol Med. 2025 Mar;178(5):681-684. doi: 10.1007/s10517-025-06397-9. Epub 2025 Apr 28.
The changes in serum concentrations of glycodelin A, placental α1-microglobulin, and adiponectin in pregnant women were studied and the possibility of using them for predicting placenta accreta spectrum (PAS) was evaluated. Significantly reduced serum levels of all studied proteins and higher number cases of cesarean sections were found in women with PAS. A formula for predicting PAS was developed. It was found that patient's score ⩾ 8 indicates the presence of PAS with high sensitivity and specificity.
研究了孕妇血清中糖蛋白A、胎盘α1-微球蛋白和脂联素浓度的变化，并评估了将它们用于预测胎盘植入谱系（PAS）的可能性。在患有PAS的女性中，发现所有研究蛋白的血清水平显著降低，剖宫产病例数更多。开发了一种预测PAS的公式。发现患者评分⩾8表明存在PAS，具有高敏感性和特异性。
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