Nagasue N, Ogawa Y, Yukaya H, Okita M, Yamamoto M, Higashi T
Gastroenterol Jpn. 1985 Apr;20(2):131-6. doi: 10.1007/BF02776676.
Portal pressure and systemic hemodynamics were evaluated for 30 minutes after intravenous injection of 400 mg of cimetidine in patients with and without liver cirrhosis when they were operated upon for varying surgical diseases. A transient fall of arterial pressure was seen in both groups of patients, but the change was statistically significant only in those with cirrhosis. Cimetidine did not substantially alter pulse rate, CVP, and portal pressure in both groups. The present results seem to indicate that rapid administration of cimetidine does not induce a fall of portal venous pressure in both cirrhotic and non-cirrhotic patients.
对患有和未患肝硬化的患者，在因各种外科疾病接受手术时，静脉注射400毫克西咪替丁后，评估门静脉压力和全身血流动力学30分钟。两组患者均出现动脉压短暂下降，但仅在肝硬化患者中这种变化具有统计学意义。西咪替丁对两组患者的心率、中心静脉压和门静脉压力均无显著影响。目前的结果似乎表明，快速给予西咪替丁不会导致肝硬化和非肝硬化患者门静脉压力下降。
