研究血浆脂质谱与帕金森病风险的关系。
Investigating plasma lipid profiles in association with Parkinson's disease risk.
作者信息
Zhang Houwen, Cao Fangzheng, Yu Jialin, Liang Yu, Wu You
机构信息
The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, China.
出版信息
NPJ Parkinsons Dis. 2025 Apr 28;11(1):99. doi: 10.1038/s41531-025-00955-8.
Parkinson's Disease (PD) is associated with lipid metabolic disturbances, but the specific roles of lipids in its pathogenesis are unclear. This Mendelian Randomization (MR) study utilized GWAS data and IVW methods to investigate plasma lipids and PD risk. The genetic predispositions to altered levels of triacylglycerols (TAGs), diacylglycerols (DAGs), phosphatidylcholines (PCs), and phosphatidylethanolamines (PEs) are associated with an increased risk of PD, while the genetic predispositions to sphingomyelin (SM) and lysophosphatidylcholines (LPCs) are associated with a reduced risk of PD. Further research is needed to establish the biological mechanisms underlying these relationships.
帕金森病（PD）与脂质代谢紊乱有关，但其发病机制中脂质的具体作用尚不清楚。这项孟德尔随机化（MR）研究利用全基因组关联研究（GWAS）数据和逆方差加权（IVW）方法来研究血浆脂质与帕金森病风险之间的关系。甘油三酯（TAGs）、甘油二酯（DAGs）、磷脂酰胆碱（PCs）和磷脂酰乙醇胺（PEs）水平改变的遗传易感性与帕金森病风险增加有关，而鞘磷脂（SM）和溶血磷脂酰胆碱（LPCs）的遗传易感性与帕金森病风险降低有关。需要进一步研究以确定这些关系背后的生物学机制。
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