Kim Hyun Jun, Park Do-Yang, Lee Wee Gyo, Lee Kang Il, Jung Jin Ji, Lee Han Sang, Hwang Sang In, Park Ji Hyun, Park Bumhee
Sleep Center, Ajou University Hospital, 164 World cup-ro, Yeongtong-gu, Suwon-si, Gyonggi-do, 16499, Republic of Korea.
Department of Otorhinolaryngology - Head and Neck Surgery, Ajou University School of Medicine, Suwon, Republic of Korea.
Sci Rep. 2025 Apr 28;15(1):14839. doi: 10.1038/s41598-025-98702-9.
We aimed to examine the effect of continuous positive airway pressure on sleep quality and alcohol metabolism after alcohol consumption. Men (n = 53) aged ≥ 19 years with sleep disorders who regularly consumed an average of ≥ 1.0 g of alcohol/kg of bodyweight, were free of serious diseases (including liver disorders), and underwent polysomnography and continuous positive airway pressure titration between January 2016 and July 2021 were included. Participants drank a high dose of a traditional Korean liquor at a rate of 1.0 g/kg of bodyweight for 1 h. The main outcome measures included polysomnography results and blood and breath ethanol and acetaldehyde concentrations after alcohol consumption before and after sleep. Statistical analyses were performed using R software, version 4.0.5 (R Foundation, Vienna, Austria). Continuous positive airway pressure enhanced sleep quality after alcohol consumption, with oxygen significantly improving the metabolism of acetaldehyde over that of ethanol. Breath and blood sample analyses and polysomnography results revealed that continuous positive airway pressure improved sleep quality by reducing apnea-hypopnea index by 27.32 ± 24.87 (p < 0.001), increasing rapid eye movement sleep by 2.08 ± 6.74% (p < 0.05), and enhancing acetaldehyde breakdown by 21.2% (p < 0.001), while its effect on ethanol breakdown (4-5%) was not statistically significant. Continuous positive airway pressure is recommended after alcohol consumption for individuals with sleep apnea to enhance sleep quality.
我们旨在研究持续气道正压通气对饮酒后睡眠质量和酒精代谢的影响。纳入了年龄≥19岁、患有睡眠障碍、平均每周饮酒量≥1.0克/千克体重、无严重疾病（包括肝脏疾病）且在2016年1月至2021年7月期间接受多导睡眠图检查和持续气道正压通气滴定的男性（n = 53）。参与者以1.0克/千克体重的速率在1小时内饮用高剂量的传统韩国白酒。主要观察指标包括多导睡眠图结果以及饮酒前后睡眠期间血液和呼出气体中的乙醇和乙醛浓度。使用R软件4.0.5版（R基金会，奥地利维也纳）进行统计分析。持续气道正压通气可提高饮酒后的睡眠质量，氧气能显著促进乙醛而非乙醇的代谢。呼出气体和血液样本分析以及多导睡眠图结果显示，持续气道正压通气通过将呼吸暂停低通气指数降低27.32±24.87（p < 0.001）、将快速眼动睡眠增加2.08±6.74%（p < 0.05）以及将乙醛分解提高21.2%（p < 0.001）来改善睡眠质量，而其对乙醇分解的影响（4 - 5%）无统计学意义。建议睡眠呼吸暂停患者饮酒后使用持续气道正压通气来提高睡眠质量。
