Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.
Department of Thoracic Medicine, Cairns Hospital, Cairns, Queensland, Australia.
Endocrinol Metab Clin North Am. 2023 Sep;52(3):509-520. doi: 10.1016/j.ecl.2023.01.006. Epub 2023 Feb 26.
Obesity is considered a twentieth-century epidemic and is a growing concern among health professionals. Obesity and its complications contribute to multiple chronic illnesses, such as type 2 diabetes (T2D), metabolic syndrome, obstructive sleep apnea (OSA), malignancy, and cardiovascular and liver diseases. In the last two decades, a bidirectional association between OSA and metabolic-associated fatty liver disease (MAFLD), independent of obesity, has been established. Both conditions have similar risk factors and metabolic comorbidities that may imply a common disease pathway. This review compiles the evidence and delineates the relationship between OSA and MAFLD from a clinical and diagnostic aspect.
肥胖被认为是 20 世纪的一种流行病，也是健康专业人员日益关注的问题。肥胖及其并发症导致多种慢性疾病，如 2 型糖尿病（T2D）、代谢综合征、阻塞性睡眠呼吸暂停（OSA）、恶性肿瘤以及心血管和肝脏疾病。在过去的二十年中，已经确定了 OSA 和代谢相关脂肪性肝病（MAFLD）之间的双向关联，而肥胖是独立的。这两种情况具有相似的危险因素和代谢合并症，这可能意味着存在共同的疾病途径。这篇综述从临床和诊断的角度汇集了 OSA 和 MAFLD 之间的证据和关系。
