Busetto Alberto, Comacchio Giovanni Maria, Verzeletti Vincenzo, Shamshoum Fares, Fortarezza Francesco, Pezzuto Federica, Dell'Amore Andrea, Calabrese Fiorella, Rea Federico
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Thoracic Surgery Unit, Division of Surgery, University - Hospital of Padua, Padua, Italy.
Thorac Cancer. 2025 Apr;16(8):e70078. doi: 10.1111/1759-7714.70078.
Bronchial carcinoids are uncommon neuroendocrine tumors. According to their pathological differentiation, they are divided into typical and atypical forms, with diverse biological behavior and aggressiveness. Bronchial carcinoids may be associated with familial neuroendocrine syndromes, such as MEN-1. They can also present initially as diffuse hyperplastic proliferation of neuroendocrine foci throughout the pulmonary parenchyma (DIPNECH). Metachronous and bilateral forms are sporadic in the literature. We describe a case of a 68-year-old man with metachronous bilateral typical-atypical carcinoid neoplasms. The patient was treated with a two-stage mini-invasive pulmonary surgery in a time frame of 5 years. This case may be unique because it features two rare and distinct pathological entities in the same patient, not associated with any known genetic mutation. Carcinoid tumors require multidisciplinary care and a collaborative approach due to their pleomorphic behavior, ensuring comprehensive management and maximizing therapeutic efficacy.
支气管类癌是罕见的神经内分泌肿瘤。根据其病理分化情况，可分为典型和非典型两种类型，具有不同的生物学行为和侵袭性。支气管类癌可能与家族性神经内分泌综合征相关，如MEN-1。它们最初也可能表现为整个肺实质内神经内分泌灶的弥漫性增生（弥漫性特发性肺神经内分泌细胞增生症）。文献中异时性和双侧性的病例较为散见。我们描述了一例68岁男性患有异时性双侧典型-非典型类癌肿瘤的病例。该患者在5年的时间内接受了两阶段的微创肺手术治疗。此病例可能较为独特，因为同一患者身上出现了两种罕见且不同的病理实体，且与任何已知基因突变均无关联。由于类癌肿瘤行为具有多形性，因此需要多学科护理和协作方法，以确保全面管理并最大限度提高治疗效果。
