Kazemi Asma, Deylami Noushin, Shojaei-Zarghani Sara, Hashempur Mohammad Hashem
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Diet Suppl. 2025;22(4):463-486. doi: 10.1080/19390211.2025.2490659. Epub 2025 Apr 28.
In this systematic review and meta-analysis of clinical trials, we investigated the effect of pomegranate on vascular endothelial function markers.
We searched PubMed, Scopus, Web of Science, and the Cochrane Library until September 2024. Clinical trials that investigated the effect of pomegranate juice, extract, or its components on markers of vascular endothelial function, including flow-mediated dilation (FMD), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, nitric oxide (NO), interleukin 6 (IL-6), IL-1, and IL-10, in healthy or diseased adults ages ≥ 18 years were eligible to be included. The quality of studies was assessed using the Cochrane tool. Random-effects meta-analysis was used to pool standardized mean differences () and 95% CI for the outcomes assessed by at least three studies.
Nineteen studies were included. Analysis of studies indicated a nonsignificant effect on VCAM-1 (: -041, 95%CI: -2.53 to 1.71, = 83.6%, = 3), while a significant reduction in ICAM-1 was observed (: -0.63, 95% CI: -0.85 to -0.40, = 0.0%, = 3). Pooled analysis of fourteen studies on IL-6 indicated a significant reduction (-0.58, 95% CI: -0.98 to -0.19, = 82.63%). The results of the three studies on E-selectin were inconsistent. The FMD and NO were assessed in only one study.
Pomegranate is effective in improving IL-6 and ICAM-1, but not VCAM-1.
在这项对临床试验的系统评价和荟萃分析中，我们研究了石榴对血管内皮功能标志物的影响。
我们检索了截至2024年9月的PubMed、Scopus、Web of Science和Cochrane图书馆。纳入了年龄≥18岁的健康或患病成年人中，研究石榴汁、提取物或其成分对血管内皮功能标志物影响的临床试验，这些标志物包括血流介导的血管舒张（FMD）、细胞间黏附分子1（ICAM-1）、血管细胞黏附分子1（VCAM-1）、E-选择素、一氧化氮（NO）、白细胞介素6（IL-6）、IL-1和IL-10。使用Cochrane工具评估研究质量。随机效应荟萃分析用于汇总至少三项研究评估的结果的标准化均值差（）和95%置信区间。
纳入了19项研究。对研究的分析表明，对VCAM-1无显著影响（：-0.41，95%置信区间：-2.53至1.71， = 83.6%， = 3），而观察到ICAM-1有显著降低（：-0.63，95%置信区间：-0.85至-0.40， = 0.0%， = 3）。对14项关于IL-6的研究的汇总分析表明有显著降低（-0.58，95%置信区间：-0.98至-0.19， = 82.63%）。关于E-选择素的三项研究结果不一致。仅在一项研究中评估了FMD和NO。
石榴在改善IL-6和ICAM-1方面有效，但对VCAM-1无效。
