慢性活动性肝炎和肝硬化患者肝血流与凝血指标之间的相关性

Correlation between hepatic blood flow and coagulation indices in chronic active hepatitis and liver cirrhosis patients.

作者信息

Violi F, Alessandri C, Saliola M, Caputo V, Bonavita M S, Balsano F

出版信息

Haemostasis. 1985;15(3):210-4. doi: 10.1159/000215146.

Abstract

Hepatic blood flow (HBF) has been reported to reflect liver cell mass. HBF was studied in 21 patients with chronic active hepatitis (CAH) and in 20 patients with liver cirrhosis (LC). It was correlated with such indices of liver protein synthesis as serum albumin, Normotest, plasma activity of antithrombin III, prekallikrein, alpha 2-antiplasmin and plasminogen. No correlation between HBF and the examined parameters was seen in CAH. HBF correlated with all the indices of liver protein synthesis in LC, thus suggesting that serum albumin, antithrombin III, Normotest, prekallikrein, plasminogen, and alpha 2-antiplasmin could reflect the residual liver cell mass in LC.

摘要

据报道，肝血流量（HBF）可反映肝细胞量。对21例慢性活动性肝炎（CAH）患者和20例肝硬化（LC）患者的肝血流量进行了研究。将其与肝脏蛋白质合成指标如血清白蛋白、诺莫测试、抗凝血酶III、前激肽释放酶、α2-抗纤溶酶和纤溶酶原的血浆活性进行关联分析。在慢性活动性肝炎患者中未发现肝血流量与所检测参数之间存在相关性。在肝硬化患者中，肝血流量与肝脏蛋白质合成的所有指标均相关，这表明血清白蛋白、抗凝血酶III、诺莫测试、前激肽释放酶、纤溶酶原和α2-抗纤溶酶可反映肝硬化患者残余的肝细胞量。