Ryzhova I V, Vershinina E A, Tobias T V
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2025 Mar;178(5):601-604. doi: 10.1007/s10517-025-06382-2. Epub 2025 Apr 29.
Interferon (IFN) used in the treatment of severe viral infections and cancer can lead to acute hearing loss and balance problems. The effect of type I interferon IFNα2b on the function of the afferent glutamatergic synapse of the vestibular epithelium was studied in vitro using electrophysiological method and perfusion of the synaptic area with solutions containing glutamate (GLU) and ionotropic glutamate receptor agonists (AMPA, NMDA). IFNα2b selectively activates AMPA, but not NMDA receptors, and modulates the afferent flow from the sensory epithelium to CNS. The delayed activation of AMPA receptors is one of the mechanisms of the neuromodulatory effect of IFNα2b on glutamatergic synaptic transmission in the vestibular apparatus.
用于治疗严重病毒感染和癌症的干扰素（IFN）可导致急性听力丧失和平衡问题。本研究采用电生理方法，并通过用含有谷氨酸（GLU）和离子型谷氨酸受体激动剂（AMPA、NMDA）的溶液灌注突触区域，在体外研究了I型干扰素IFNα2b对前庭上皮传入性谷氨酸能突触功能的影响。IFNα2b选择性激活AMPA受体，但不激活NMDA受体，并调节从感觉上皮到中枢神经系统的传入信息流。AMPA受体的延迟激活是IFNα2b对前庭器官谷氨酸能突触传递神经调节作用的机制之一。
