Kuznetsova T E, Mityukova T A, Basalai A A, Darenskaya M A, Rychkova L V, Kolesnikov S I, Semenova N V, Kolesnikova L I
Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Republic of Belarus.
Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2025 Mar;178(5):647-653. doi: 10.1007/s10517-025-06391-1. Epub 2025 Apr 29.
We studied the histological structure of the hippocampus in male and female Wistar rats kept on a standard vivarium diet (StD) or a high-calorie diet (HCD) for 16 weeks. The effect of diet-induced visceral obesity correction was also evaluated. To this end, the rats receiving HCD for 8 weeks were transferred to StD for the next 8 weeks. HCD for 16 weeks led to diet-induced visceral obesity and disturbances in the histological structure of the hippocampus in both males and females. The most typical consequences of HCD were neurodegenerative signs, which appeared in different regions of the hippocampus. Transition to StD was effective not only in correcting visceral obesity, but also in leveling neurodegenerative changes in the structure of hippocampal neurons in male and female rats.
我们研究了雄性和雌性Wistar大鼠的海马组织学结构，这些大鼠分别以标准饲养饮食（StD）或高热量饮食（HCD）喂养16周。我们还评估了饮食诱导的内脏肥胖纠正效果。为此，接受8周HCD的大鼠在接下来的8周被转移至StD饮食。16周的HCD导致了饮食诱导的内脏肥胖以及雄性和雌性大鼠海马组织结构紊乱。HCD最典型的后果是神经退行性体征，出现在海马的不同区域。转换至StD不仅有效纠正了内脏肥胖，还使雄性和雌性大鼠海马神经元结构中的神经退行性变化趋于平稳。
