Abramov A A, Lakomkin V L, Prosvirnin A V, Kuzmin V S
National Medical Research Centre of Cardiology named after academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia.
Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2025 Mar;178(5):586-592. doi: 10.1007/s10517-025-06379-x. Epub 2025 Apr 29.
Pulmonary arterial hypertension (PAH) is accompanied by changes in the pulmonary and systemic circulation. We studied the effect of PAH on the function of the left ventricle (LV). Left ventricular pressure and volume were simultaneously recorded in vivo in rats with monocrotaline-induced PAH (60 mg/kg). LV contractility and mechanical indexes were calculated. In addition, the relationships between LV maximum rate of contraction (dP/dt) or relaxation (dP/dt) and left ventricular end-diastolic volume (EDV) were assessed. PAH leads to a significant decrease in cardiac output at a constant HR as well as to a decrease in stroke volume at unchanged LV ejection fraction. In rats with PAH, the slopes of the dP/dt-EDV and dP/dt-EDV curves were greater than in control animals by 1.93 and 2.5 times, respectively. Thus, PAH leads to a compensatory increase in the dependence of LV contractility and "intensity" of LV relaxation on EDV.
肺动脉高压（PAH）伴有肺循环和体循环的改变。我们研究了PAH对左心室（LV）功能的影响。在给予60mg/kg野百合碱诱导PAH的大鼠体内同时记录左心室压力和容积。计算左心室收缩性和力学指标。此外，评估左心室最大收缩速率（dP/dt）或舒张速率（dP/dt）与左心室舒张末期容积（EDV）之间的关系。在恒定心率下，PAH导致心输出量显著降低，且在左心室射血分数不变的情况下导致每搏输出量减少。在PAH大鼠中，dP/dt-EDV和dP/dt-EDV曲线的斜率分别比对照动物大1.93倍和2.5倍。因此，PAH导致左心室收缩性和左心室舒张“强度”对EDV的依赖性代偿性增加。
