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亚太地区免疫功能低下和自身免疫性疾病成人带状疱疹风险的系统评价与荟萃分析

A systematic review and meta-analysis of herpes zoster risk in adults with immunocompromised conditions and autoimmune diseases in Asia-Pacific.

作者信息

Chen Jing, Ho Chin-Yen, Tu Yu-Kang, Lin Yi-Chih, Hsia Yun, Lin Ying-Chun, Shantakumar Sumitra

机构信息

GSK, Singapore.

Health Data Research Center, National Taiwan University, Taipei, Taiwan.

出版信息

Hum Vaccin Immunother. 2025 Dec;21(1):2496048. doi: 10.1080/21645515.2025.2496048. Epub 2025 Apr 29.

DOI:10.1080/21645515.2025.2496048
PMID:40299930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12045574/
Abstract

Asia-Pacific (APAC) faces an increasing burden of herpes zoster (HZ) over time. The risk of HZ and its complications are increased in immunocompromised (IC) patients and those with autoimmune diseases (AID). Our study aimed to synthesize evidence on the epidemiological burden of HZ and its complications among the general adult population and patients with IC/AID conditions in APAC. Following a systematic literature review, we performed meta-analyses for outcomes where ≥3 studies met the inclusion criteria. Of the 271 articles identified, 75 were included for meta-analysis. We found a high burden of HZ and its complications (i.e., postherpetic neuralgia, HZ ophthalmicus), particularly among individuals with IC/AID conditions in APAC. Patients with IC/AID conditions had significantly increased HZ risk and a higher proportion of HZ recurrence than the general adult population. These findings may inform clinical practice and public health decisions regarding HZ prevention, including HZ vaccination strategies, among the IC/AID population in APAC.

摘要

随着时间的推移，亚太地区（APAC）带状疱疹（HZ）的负担日益加重。免疫功能低下（IC）患者和自身免疫性疾病（AID）患者发生HZ及其并发症的风险会增加。我们的研究旨在综合亚太地区普通成年人群以及IC/AID患者中HZ及其并发症的流行病学负担的证据。在进行系统的文献综述之后，我们对≥3项研究符合纳入标准的结局进行了荟萃分析。在确定的271篇文章中，75篇被纳入荟萃分析。我们发现HZ及其并发症（即带状疱疹后神经痛、眼部带状疱疹）的负担很重，尤其是在亚太地区的IC/AID患者中。与普通成年人群相比，IC/AID患者发生HZ的风险显著增加，且HZ复发的比例更高。这些发现可能为亚太地区IC/AID人群中有关HZ预防（包括HZ疫苗接种策略）的临床实践和公共卫生决策提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/7a5e0cc585dc/KHVI_A_2496048_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/40c3e93b28b7/KHVI_A_2496048_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/4b3c2728899b/KHVI_A_2496048_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/9f57b0b49671/KHVI_A_2496048_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/8e2afd2c113e/KHVI_A_2496048_F0003a_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/3e4794a341c6/KHVI_A_2496048_F0003b_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/03681dc9c48d/KHVI_A_2496048_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/0fb5af0d96fe/KHVI_A_2496048_F0005a_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/fa74334c242c/KHVI_A_2496048_F0005b_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/7a5e0cc585dc/KHVI_A_2496048_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/40c3e93b28b7/KHVI_A_2496048_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/4b3c2728899b/KHVI_A_2496048_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/9f57b0b49671/KHVI_A_2496048_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/8e2afd2c113e/KHVI_A_2496048_F0003a_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/3e4794a341c6/KHVI_A_2496048_F0003b_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/03681dc9c48d/KHVI_A_2496048_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/0fb5af0d96fe/KHVI_A_2496048_F0005a_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/fa74334c242c/KHVI_A_2496048_F0005b_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43f7/12045574/7a5e0cc585dc/KHVI_A_2496048_F0006_B.jpg

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本文引用的文献

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Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK.欧盟/欧洲经济区、瑞士和英国疾病风险增加人群中带状疱疹发病率的系统文献综述。
Infect Dis Ther. 2024 May;13(5):1083-1104. doi: 10.1007/s40121-024-00963-w. Epub 2024 Apr 24.
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Herpes Zoster Recurrence: A Narrative Review of the Literature.
带状疱疹复发：文献综述
Dermatol Ther (Heidelb). 2024 Mar;14(3):569-592. doi: 10.1007/s13555-024-01101-7. Epub 2024 Feb 28.
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