Cao Tingping, Zhou Quanling, Li Fujun, Wang Mingyue, Zhang Ming, Li Xiaohui, Zhao Hailong, Zhou Ya
Department of Pathophysiology, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Department of Physics, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
J Transl Med. 2025 Apr 29;23(1):485. doi: 10.1186/s12967-025-06499-y.
Dual-specific phosphatase-8 (DUSP8), identified as the first gene in a genome-wide association study (GWAS), is implicated in cellular oxidative stress, proliferation, apoptosis, and drug resistance through its negative regulation of the dephosphorylation activities of JNK, ERK, and p38 within the MAPK pathway. Recent studies have shown that DUSP8 plays a pivotal role in the progression of several human diseases, notably colorectal cancer, diabetic kidney disease, and breast cancer. This suggests that DUSP8 may represent a novel target for clinical intervention in these diseases. This review first introduces the biological structure and function of DUSP8, with a focus on its relationship with a series of diseases and the regulatory mechanisms involved. Furthermore, we concentrate on unresolved scientific questions in the current research, aiming to establish a new theoretical foundation for the diagnosis and treatment of related diseases.
双特异性磷酸酶8（DUSP8）是在全基因组关联研究（GWAS）中鉴定出的首个基因，它通过对丝裂原活化蛋白激酶（MAPK）途径中JNK、ERK和p38的去磷酸化活性进行负调控，参与细胞氧化应激、增殖、凋亡和耐药过程。最近的研究表明，DUSP8在几种人类疾病的进展中起关键作用，尤其是结直肠癌、糖尿病肾病和乳腺癌。这表明DUSP8可能是这些疾病临床干预的新靶点。本综述首先介绍DUSP8的生物学结构和功能，重点关注其与一系列疾病的关系及相关调控机制。此外，我们聚焦于当前研究中尚未解决的科学问题，旨在为相关疾病的诊断和治疗建立新的理论基础。
