Miao Miao, Chen Yuelei, Wang Xuehan, Li Shengyang, Hu Rong
Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, China.
Virulence. 2025 Dec;16(1):2497908. doi: 10.1080/21505594.2025.2497908. Epub 2025 Apr 29.
Epstein-Barr Virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and human T-cell leukemia virus type 1 (HTLV-1) are key infectious agents linked to the development of various hematological malignancies, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, and adult T-cell leukemia/lymphoma. This review highlights the critical knowledge gaps in understanding the role of ferroptosis, a novel form of cell death, in virus-related tumors. We focus on how ferroptosis influences the host cell response to these viral infections, revealing groundbreaking mechanisms by which the three viruses differentially regulate core pathways of ferroptosis, such as iron homeostasis, lipid peroxidation, and antioxidant systems, thereby promoting malignant transformation of host cells. Additionally, we explore the potential of antiviral drugs and ferroptosis modulators in the treatment of virus-associated hematological malignancies.
爱泼斯坦-巴尔病毒（EBV）、卡波西肉瘤相关疱疹病毒（KSHV）和人类T细胞白血病病毒1型（HTLV-1）是与多种血液系统恶性肿瘤发生相关的关键感染因子，这些肿瘤包括霍奇金淋巴瘤、非霍奇金淋巴瘤和成人T细胞白血病/淋巴瘤。本综述着重强调了在理解铁死亡（一种新型细胞死亡形式）在病毒相关肿瘤中的作用方面存在的关键知识空白。我们关注铁死亡如何影响宿主细胞对这些病毒感染的反应，揭示这三种病毒以不同方式调节铁死亡核心途径（如铁稳态、脂质过氧化和抗氧化系统）从而促进宿主细胞恶性转化的开创性机制。此外，我们还探讨了抗病毒药物和铁死亡调节剂在治疗病毒相关血液系统恶性肿瘤方面的潜力。
