病毒白细胞介素-6在卡波西肉瘤相关疱疹病毒介导的免疫逃逸和肿瘤发生中的作用

The Role of vIL-6 in KSHV-Mediated Immune Evasion and Tumorigenesis.

作者信息

Komaki Somayeh, Inagaki Tomoki, Kumar Ashish, Izumiya Yoshihiro

机构信息

Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.

出版信息

Viruses. 2024 Dec 10;16(12):1900. doi: 10.3390/v16121900.

DOI:10.3390/v16121900

PMID:39772207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11680145/

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA gamma herpesvirus. Like other herpesviruses, KSHV establishes a latent infection with limited gene expression, while KSHV occasionally undergoes the lytic replication phase, which produces KSHV progenies and infects neighboring cells. KSHV genome encodes 80+ open reading frames. One of the KSHV genes, K2, encodes viral interleukin 6 (vIL-6), a homolog of human IL-6 (hIL-6), mainly expressed in the lytic phase of the virus. vIL-6 plays a crucial role in regulating the expression of other viral genes and is also associated with inducing angiogenesis, cell survival, and immune evasion, which is suggested to promote the development of KSHV-associated diseases. This review summarizes the current knowledge on vIL-6. We focus on the vIL-6 regarding its protein structure, transcriptional regulation, cell signaling pathways, and contribution to the KSHV-associated diseases.

摘要

卡波西肉瘤相关疱疹病毒（KSHV）是一种双链DNAγ疱疹病毒。与其他疱疹病毒一样，KSHV建立一种基因表达受限的潜伏感染，而KSHV偶尔会经历裂解复制阶段，产生KSHV子代并感染邻近细胞。KSHV基因组编码80多个开放阅读框。KSHV基因之一K2编码病毒白细胞介素6（vIL-6），它是人类IL-6（hIL-6）的同源物，主要在病毒的裂解期表达。vIL-6在调节其他病毒基因的表达中起关键作用，还与诱导血管生成、细胞存活和免疫逃逸有关，这被认为会促进KSHV相关疾病的发展。本综述总结了目前关于vIL-6的知识。我们重点关注vIL-6的蛋白质结构、转录调控、细胞信号通路以及对KSHV相关疾病的作用。