Shuai Xueqian, Sun Yaoqi, Liu Shupeng, Cheng Zhongping
Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200040, China.
Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai, 200434, China.
J Cancer. 2025 Apr 9;16(7):2353-2359. doi: 10.7150/jca.103209. eCollection 2025.
Alternative splicing is an evolutionarily conserved and essential cellular process that is catalyzed by a multi-complex spliceosome. Dysregulation of this process has been implicated in various tumors over the recent years. is a critical subunit of U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome, which has been found to be aberrant in several human diseases. Recent reports suggest that might be a novel therapeutic target. However, a comprehensive description of is lacking. In this review, we present the findings of from protein structure, biological function to strong associations with human diseases including cancer. Studies have reported that dysregulation and associated alternative splicing events mediate tumorigenesis and other immune-related disorders. However, further functional and mechanistic studies are needed to fully understand the regulatory network of in human diseases. In conclusion, could serve as a promising prognostic biomarker and therapeutic target for specific cancer types, including prostate cancer, colorectal cancer and hepatocellular carcinoma.
可变剪接是一种由多复合物剪接体催化的、在进化上保守且必不可少的细胞过程。近年来，该过程的失调与多种肿瘤有关。（此处原文缺失关键信息）是剪接体中U2小核核糖核蛋白（snRNP）的一个关键亚基，已发现在几种人类疾病中存在异常。最近的报告表明，（此处原文缺失关键信息）可能是一个新的治疗靶点。然而，目前缺乏对（此处原文缺失关键信息）的全面描述。在本综述中，我们展示了（此处原文缺失关键信息）从蛋白质结构、生物学功能到与包括癌症在内的人类疾病的紧密关联等方面的研究结果。研究报告称，（此处原文缺失关键信息）失调及相关的可变剪接事件介导肿瘤发生和其他免疫相关疾病。然而，需要进一步的功能和机制研究来全面了解（此处原文缺失关键信息）在人类疾病中的调控网络。总之，（此处原文缺失关键信息）可作为包括前列腺癌、结直肠癌和肝细胞癌在内的特定癌症类型的一个有前景的预后生物标志物和治疗靶点。
