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痔疮治疗的最新研究趋势

Latest Research Trends on the Management of Hemorrhoids.

作者信息

Kang Sung Il

机构信息

Department of Surgery, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea.

出版信息

J Anus Rectum Colon. 2025 Apr 25;9(2):179-191. doi: 10.23922/jarc.2024-090. eCollection 2025.

DOI:10.23922/jarc.2024-090
PMID:40302863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12035339/
Abstract

Hemorrhoids manifest with a range of symptoms and severities, prompting the development of various conservative, interventional, and surgical treatments. Selecting the most suitable treatment for each case is challenging, especially with the continuous evolution of new methods. This review aims to advance hemorrhoid treatment and research by exploring recent developments over the last five years. Conservative approaches have focused on isolating active ingredients from traditional herbal remedies to create new products and understand their mechanisms. In office-based treatments, advanced devices such as modified rubber band ligation and polymer clips with stronger binding forces have been introduced. Polidocanol in foam form has shown promise in sclerotherapy, while infrared coagulation is being replaced by alternative energy-based methods. Additionally, endoscopic office treatments and embolization of hemorrhoidal vessels via angiography are increasingly used as safer options for patients with high surgical risks or bleeding issues. Stapled hemorrhoidopexy has shifted to partial resection instead of complete circular resection, and hemorrhoidal artery ligation techniques have been reported to be effective when combined with stapled hemorrhoidopexy or excisional hemorrhoidectomy in severe cases. Evidence is growing that hemorrhoidal artery ligation remains effective even without Doppler guidance. With ongoing research into various methods, there is a need for scientific comparison and evaluation of their advantages and disadvantages, standardization of indicators and treatment protocols, and cost-effectiveness considerations. Surgeons should offer well-informed options and explanations to patients, based on a comprehensive understanding of available treatments.

摘要

痔疮表现出一系列症状和严重程度,促使人们开发出各种保守、介入和手术治疗方法。为每个病例选择最合适的治疗方法具有挑战性,尤其是随着新方法的不断发展。本综述旨在通过探讨过去五年的最新进展来推进痔疮治疗和研究。保守方法侧重于从传统草药中分离活性成分以创造新产品并了解其作用机制。在门诊治疗中,已引入了先进的设备,如改良的橡皮筋结扎术和具有更强约束力的聚合物夹子。泡沫形式的聚多卡醇在硬化疗法中显示出前景,而基于替代能量的方法正在取代红外线凝固法。此外,内镜门诊治疗和通过血管造影对痔血管进行栓塞越来越多地被用作手术风险高或有出血问题患者的更安全选择。吻合器痔上黏膜环切术已转向部分切除而非完全环形切除,并且据报道,在严重病例中,痔动脉结扎技术与吻合器痔上黏膜环切术或痔切除术联合使用时有效。越来越多的证据表明,即使没有多普勒引导,痔动脉结扎术仍然有效。随着对各种方法的不断研究,需要对其优缺点进行科学比较和评估,对指标和治疗方案进行标准化,并考虑成本效益。外科医生应在全面了解现有治疗方法的基础上,为患者提供充分知情的选择和解释。

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1
Latest Research Trends on the Management of Hemorrhoids.痔疮治疗的最新研究趋势
J Anus Rectum Colon. 2025 Apr 25;9(2):179-191. doi: 10.23922/jarc.2024-090. eCollection 2025.
2
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[Necessary and unnecessary treatment options for hemorrhoids].[痔疮的必要与不必要治疗方案]
Ther Umsch. 2014 Dec;71(12):737-51. doi: 10.1024/0040-5930/a000620.
4
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Minimally Invasive Treatment for Advanced Hemorrhoids.晚期痔疮的微创治疗
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LONG TERM RESULTS AFTER STAPLED HEMORRHOIDOPEXY ALONE AND COMPLEMENTED BY EXCISIONAL HEMORRHOIDECTOMY: A RETROSPECTIVE COHORT STUDY.单纯吻合器痔上黏膜环切术及联合外剥内扎术治疗痔疮的长期疗效:一项回顾性队列研究
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THD Doppler: A Reliable Surgical Procedure to Treat Hemorrhoids.THD多普勒:一种治疗痔疮的可靠外科手术。
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Stapled versus conventional surgery for hemorrhoids.吻合器痔上黏膜环切术与传统手术治疗痔疮的对比
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Hemorrhoids: Diagnosis and Treatment Options.痔疮:诊断与治疗选择。
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本文引用的文献

1
Endoscopic polidocanol foam sclerobanding for the treatment of grade II-III internal hemorrhoids: A prospective, multi-center, randomized study.内镜下聚多卡醇泡沫硬化套扎术治疗Ⅱ-Ⅲ度内痔:一项前瞻性、多中心、随机研究。
World J Gastroenterol. 2024 Jul 21;30(27):3326-3335. doi: 10.3748/wjg.v30.i27.3326.
2
Revealing the Molecular Mechanism of Sageretia theezans in the Treatment of Hemorrhoids based on Network Pharmacology.基于网络药理学揭示雀梅藤治疗痔疮的分子机制
Comb Chem High Throughput Screen. 2024 Jun 26. doi: 10.2174/0113862073288546240528085144.
3
Laser hemorrhoidoplasty vs. rubber band ligation: a randomized trial comparing 2 mini-invasive treatment for grade II hemorrhoids.
激光痔切除术与橡皮圈结扎术治疗Ⅱ度痔的随机对照研究
BMC Surg. 2024 May 27;24(1):164. doi: 10.1186/s12893-024-02425-z.
4
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Hemorrhoids.美国结肠和直肠外科医师协会痔疮管理临床实践指南。
Dis Colon Rectum. 2024 May 1;67(5):614-623. doi: 10.1097/DCR.0000000000003276. Epub 2024 Jan 31.
5
Sclerobanding in the treatment of second and third degree hemorrhoidal disease in high risk patients on antiplatelet/anticoagulant therapy without suspension: a pilot study.在不中断抗血小板/抗凝治疗的高危患者中,硬化剂注射治疗二度和三度痔病的一项初步研究。
Front Surg. 2023 Nov 6;10:1290706. doi: 10.3389/fsurg.2023.1290706. eCollection 2023.
6
Clinical efficacy of ultrasound doppler-guided hemorrhoidal artery ligation combined with procedure for prolapse and hemorrhoids in treatment of severe hemorrhoids.超声多普勒引导下痔动脉结扎术联合痔切除术治疗重度痔的临床疗效。
Medicine (Baltimore). 2023 Nov 24;102(47):e36189. doi: 10.1097/MD.0000000000036189.
7
Comparison of Laser Hemorrhoidoplasty and Milligan-Morgan Hemorrhoidectomy Techniques in the Treatment of Grade 2 and 3 Hemorrhoidal Disease.激光痔切除术与Milligan-Morgan痔切除术治疗2级和3级痔病的比较。
Am Surg. 2024 Apr;90(4):662-671. doi: 10.1177/00031348231207301. Epub 2023 Oct 17.
8
Milligan-Morgan hemorrhoidectomy combined with non-doppler hemorrhoidal artery ligation for the treatment of grade III/IV hemorrhoids: a single centre retrospective study.吻合器痔上黏膜环切术联合多普勒痔动脉结扎术治疗Ⅲ/Ⅳ度痔的单中心回顾性研究。
BMC Gastroenterol. 2023 Aug 31;23(1):293. doi: 10.1186/s12876-023-02933-x.
9
Excisional Hemorrhoidectomy Versus Dearterialization With Mucopexy for the Treatment of Grade III Hemorrhoidal Disease: The EMODART3 Multicenter Study.切除痔核术与黏膜固定术治疗 III 度痔病的对比:EMODART3 多中心研究。
Dis Colon Rectum. 2023 Dec 1;66(12):e1254-e1263. doi: 10.1097/DCR.0000000000002885. Epub 2023 Aug 24.
10
Endoscopic approaches to the management of hemorrhoids.痔的内镜治疗方法。
Curr Opin Gastroenterol. 2023 Sep 1;39(5):375-380. doi: 10.1097/MOG.0000000000000960. Epub 2023 Jun 21.