Carvalho-Ribeiro Igor A, Cunha Letícia C F, Ribeiro Lorena R, Lima Matheus N, Ferreira-Silva Breno A, S Rajão Juliana, Bittencourt Juliana C, F A Pinheiro Juliana, Rodrigues-Machado Maria da Glória
Faculty of Medical Sciences of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Endocrinology Service, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Pediatr Diabetes. 2024 Apr 17;2024:9919121. doi: 10.1155/2024/9919121. eCollection 2024.
Cardiovascular disease (CVD) is highly prevalent in patients with type 1 diabetes (T1DM) and is responsible for a significant reduction in life expectancy.
To compare the arterial stiffness indices, arterial compliance and vascular resistance assessed centrally and peripherally between healthy adolescents and young adults (CTRL group) and those with T1DM.
This is an observational cross-sectional study involving 90 adolescents and young adults, with half of them being considered healthy ( = 45) and the other half with T1DM ( = 45), matched by age and sex. Cardiovascular parameters were evaluated using the oscillometric method of brachial artery pressure assessment for a noninvasive estimation of central arterial pressures.
Weight and body mass index were significantly higher in the T1DM group. AIx@75 was significantly higher in the T1DM group (24.96% ± 8.88%) compared to the CTRL (20.16% ± 9.95%). Peripheral and central arterial compliance were significantly lower in the T1DM group (0.79 ± 0.21; 1.16 ± 0.27 ml/m/mmHg) compared to the CTRL (0.98 ± 0.32; 1.47 ± 0.61 ml/m/mmHg). Peripheral and central vascular resistance were significantly higher in the T1DM group (1.32 ± 0.32; 0.91 ± 0.21 mmHg/ml/m) compared to the CTRL (1.11 ± 0.30; 0.75 ± 0.22 mmHg/ml/m).
Our data confirm premature aging of the vascular system in adolescents and young adults with T1DM and extend our knowledge by showing important changes in central and peripheral hemodynamics indices.
心血管疾病（CVD）在1型糖尿病（T1DM）患者中高度流行，是导致预期寿命显著缩短的原因。
比较健康青少年和年轻人（对照组）与T1DM患者的中心和外周动脉僵硬度指数、动脉顺应性和血管阻力。
这是一项观察性横断面研究，涉及90名青少年和年轻人，其中一半被视为健康者（n = 45），另一半患有T1DM（n = 45），按年龄和性别匹配。使用肱动脉压力评估的示波法评估心血管参数，以无创估计中心动脉压。
T1DM组的体重和体重指数显著更高。与对照组（20.16%±9.95%）相比，T1DM组的AIx@75显著更高（24.96%±8.88%）。与对照组（0.98±0.32；1.47±0.61 ml/m/mmHg）相比，T1DM组的外周和中心动脉顺应性显著更低（0.79±0.21；1.16±0.27 ml/m/mmHg）。与对照组（1.11±0.30；0.75±0.22 mmHg/ml/m）相比，T1DM组的外周和中心血管阻力显著更高（1.32±0.32；0.91±0.21 mmHg/ml/m）。
我们的数据证实了患有T1DM的青少年和年轻人血管系统过早老化，并通过显示中心和外周血流动力学指数的重要变化扩展了我们的认识。
