NLRP3炎性小体在口腔鳞状细胞癌中的作用
The Role of NLRP3 Inflammasome in Oral Squamous Cell Carcinoma.
作者信息
Shi Rui, Zhuang Xuan, Liu Tong, Yao Song-Nan, Xue Feng-Shan
机构信息
Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University 266600, Qingdao, 266555, People's Republic of China.
School of Stomatology of Qingdao University, Qingdao, 266555, People's Republic of China.
出版信息
J Inflamm Res. 2025 Apr 25;18:5601-5609. doi: 10.2147/JIR.S512770. eCollection 2025.
BACKGROUND
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck. More and more evidence emphasizes the importance of inflammation in the progression of OSCC. The main signaling pathway of acute and chronic inflammation consists of the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome.
OBJECTIVE
This review focuses on the role of NLRP3 immune kinase body and giving a contribution to the development of new treatment strategies against OSCC.
CONCLUSION
The NLRP3 inflammasome plays a vital role in the pathogenesis and development of OSCC and may serve as a promising therapeutic target for autoimmune diseases.
背景
口腔鳞状细胞癌（OSCC）是头颈部最常见的恶性肿瘤。越来越多的证据强调炎症在OSCC进展中的重要性。急性和慢性炎症的主要信号通路包括含3个吡咯结构域的NLR家族（NLRP3）炎性小体的激活。
目的
本综述聚焦于NLRP3免疫激酶体的作用，并为开发针对OSCC的新治疗策略做出贡献。
结论
NLRP3炎性小体在OSCC的发病机制和发展中起着至关重要的作用，可能成为自身免疫性疾病的一个有前景的治疗靶点。
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