Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, The Third Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
J Exp Med. 2021 Jun 7;218(6). doi: 10.1084/jem.20210518. Epub 2021 May 12.
Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. This review focuses on new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease. Understanding the immunological characteristics and activity of ferroptotic death not only illuminates an intersection between cell death and immunity but may also lead to the development of novel treatment approaches for immunopathological diseases.
铁死亡是一种由铁毒性、脂质过氧化和细胞膜损伤共同引发的调节性细胞坏死。铁死亡的上游诱导剂可以分为两类（生物诱导剂和化学诱导剂），并激活两条主要通路（外在/转运体通路和内在/酶学通路）。铁死亡性细胞死亡的过度或不足与一系列生理和病理生理过程相关联，并伴有免疫反应失调。本综述重点介绍了与铁死亡细胞及其释放内容如何在健康和疾病中塑造固有和适应性免疫相关的新发现。理解铁死亡死亡的免疫学特征和活性不仅阐明了细胞死亡和免疫之间的一个交汇点，还可能为免疫病理疾病的治疗方法提供新的思路。
