Pollé Olivier G, Delfosse Antoine, Michoux Nicolas, Peeters Frank, Duchêne Gaetan, Louis Jacques, Van Nieuwenhuyse Brieuc, Clapuyt Philippe, Lysy Philippe A
Pôle PEDI, Institut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, Belgium.
Specialized Pediatrics Service, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Pediatr Diabetes. 2023 Sep 22;2023:3295812. doi: 10.1155/2023/3295812. eCollection 2023.
To perform a longitudinal characterization of the pancreas in patients with new-onset T1D and investigate the correlations between magnetic resonance imaging (MRI) parameters and pancreatic functions during the first year postdiagnosis.
Thirty-one pediatric patients with new-onset T1D and 29 retrospective age-, body mass index-, and sex-matched controls were included in the study. Following hypotheses were investigated: (H1) the value of pancreas volume (PV) parameters in T1D and in controls, (H2) the association between MRI parameters and markers of pancreatic functions, (H3) the ability of MRI parameters to predict glucose homeostasis, (H4) the longitudinal evolution of MRI parameters and glucose homeostasis, -organ (whole pancreas) and -subregion (head, body, and tail).
Patients with new-onset T1D demonstrated a significant decrease of PV at diagnosis compared to controls (-45%), with prepubertal patients having increased pancreas atrophy (+25%) (H1). PV parameters were correlated with C-peptide, and trypsinogen (PV and PV, respectively). Biparametric regression models including MRI parameters predicted pancreas functions during the first year postdiagnosis (H3). Longitudinal evolution of PV parameters at 1 year postdiagnosis was correlated with PV at diagnosis ( = -0.72) but not with markers of glucose homeostasis (H4).
Our study shows that longitudinal analysis of pancreases of children with T1D using multiparametric MRI improve the understanding of T1D heterogeneity both in the context of its onset and its evolution.
对新诊断的1型糖尿病患者的胰腺进行纵向特征分析，并研究诊断后第一年磁共振成像（MRI）参数与胰腺功能之间的相关性。
本研究纳入了31例新诊断的1型糖尿病儿科患者以及29例回顾性年龄、体重指数和性别匹配的对照。研究了以下假设：（H1）1型糖尿病患者和对照中胰腺体积（PV）参数的值；（H2）MRI参数与胰腺功能标志物之间的关联；（H3）MRI参数预测葡萄糖稳态的能力；（H4）MRI参数和葡萄糖稳态的纵向演变——器官（全胰腺）和亚区域（头、体和尾）。
与对照相比，新诊断的1型糖尿病患者在诊断时PV显著降低（-45%），青春期前患者胰腺萎缩增加（+25%）（H1）。PV参数与C肽和胰蛋白酶原相关（分别为PV和PV）。包含MRI参数的双参数回归模型预测了诊断后第一年的胰腺功能（H3）。诊断后1年PV参数的纵向演变与诊断时的PV相关（= -0.72），但与葡萄糖稳态标志物无关（H4）。
我们的研究表明，使用多参数MRI对1型糖尿病儿童的胰腺进行纵向分析，有助于更好地理解1型糖尿病在发病和演变过程中的异质性。
