Michailidou Iliana, Patsiarika Anastasia, Kesidou Evangelia, Boziki Marina Kleopatra, Parisis Dimitrios, Bakirtzis Christos, Chroni Elisabeth, Grigoriadis Nikolaos
Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
AstraZeneca, Medical Affairs Department Rare Disease, Athens, Greece.
Front Immunol. 2025 Apr 15;16:1526317. doi: 10.3389/fimmu.2025.1526317. eCollection 2025.
The complement system is a key component of the innate immune system. In antiacetylcholine receptor (AChR) antibody-positive (Ab+) generalized myasthenia gravis (MG), complement activation has long been considered a principal driver of pathology. Understanding the role of complement in AChR-Ab+ generalized MG has gained increasing importance in recent years, as anticomplement drugs have been approved for clinical use or are undergoing phase II/III clinical trials. This review aims to discuss recent and previous findings on the role of complement in AChR-Ab+ MG pathology, including its interaction with pathogenic antibodies and mechanisms beyond the classical pathway activation.
补体系统是固有免疫系统的关键组成部分。在抗乙酰胆碱受体（AChR）抗体阳性（Ab+）的全身性重症肌无力（MG）中，补体激活长期以来一直被认为是病理过程的主要驱动因素。近年来，随着抗补体药物已获批用于临床或正在进行II/III期临床试验，了解补体在AChR-Ab+全身性MG中的作用变得越来越重要。本综述旨在讨论补体在AChR-Ab+ MG病理中的作用的最新及既往研究结果，包括其与致病性抗体的相互作用以及经典途径激活之外的机制。
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