用电鳐乙酰胆碱受体脂质体激活重症肌无力患者血浆中的补体。
Complement activation in myasthenia gravis plasma by Torpedo acetylcholine receptor liposomes.
作者信息
DuPont B L, Koethe S M, McQuillen M P
出版信息
Immunol Invest. 1985 Oct;14(5):415-20. doi: 10.3109/08820138509047609.
The purpose of this study was to determine if antibodies from patients with myasthenia gravis (MG) react in a biologically relevant manner with membrane bound Torpedo californica acetylcholine receptor (AChR). Antibody-mediated complement activation was measured in plasma from 15 patients with MG and 9 controls following incubation with Torpedo AChR-rich membrane vesicles (AChR liposomes). Significantly more (p less than 0.001) complement activation occurred in the patient samples compared with the controls. Torpedo AChR liposomes are well characterized and have been widely used to study the structure and function of AChR. These results suggest that Torpedo AChR liposomes may also be used in immunologic studies with autoantibodies from patients with MG.
本研究的目的是确定重症肌无力（MG）患者的抗体是否以生物学相关方式与膜结合的加州电鳐乙酰胆碱受体（AChR）发生反应。在15例MG患者和9例对照的血浆中，与富含电鳐AChR的膜囊泡（AChR脂质体）孵育后，测量抗体介导的补体激活情况。与对照组相比，患者样本中补体激活明显更多（p小于0.001）。电鳐AChR脂质体具有良好的特征，已被广泛用于研究AChR的结构和功能。这些结果表明，电鳐AChR脂质体也可用于对MG患者自身抗体的免疫学研究。
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