Yu Teng-Hung, Tang Wei-Hua, Lee Thung-Lip, Hsuan Chin-Feng, Hsu Chia-Chang, Wang Chao-Ping, Wei Ching-Ting, Cheng Min-Chih, Chung Fu-Mei, Lee Yau-Jiunn, Tsai I-Ting
Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
Int J Med Sci. 2025 Mar 31;22(9):2020-2030. doi: 10.7150/ijms.108111. eCollection 2025.
Transcription factor 7-like 2 (TCF7L2) is a key member of the T-cell factor/lymphoid enhancer factor family, and it plays a pivotal role in human physiological processes and has been implicated in various pathological conditions. TCF7L2 has been associated with inflammation, metabolic regulation, and the development of atherosclerosis. Notably, TCF7L2 exerts an anti-atherosclerotic effect by activating specific molecular pathways. Furthermore, polymorphisms have been associated with the severity of coronary artery disease (CAD) and related mortality. This study aimed to investigate whether the gene polymorphism rs77961654 A/C influences the risk of CAD. A total of 262 patients with acute coronary syndrome (ACS), 313 patients with stable angina, and 488 healthy individuals were enrolled. The rs77961654 variant of was genotyped. The frequency of the CC genotype of was higher in the stable angina and ACS groups compared to the healthy controls. After adjusting for confounding factors including age, sex, systolic blood pressure, body mass index, fasting blood glucose, total cholesterol, triglycerides, and smoking status, the CC genotype was associated with 10.46-fold and 8.00-fold higher risks of ACS and stable angina, respectively, than the AA genotype. In addition, the CC genotype was positively correlated with both stable angina and ACS, while the AA genotype was negatively correlated with ACS. Furthermore, the patients with stable angina or ACS carrying the CC genotype had significantly elevated levels of HbA1C, total white blood cell count, and lymphocyte count, and lower levels of adiponectin and secreted frizzled-related protein 5 compared to those with the AA genotype. A significant association was also identified between gene polymorphisms and type 2 diabetes mellitus (p for trend < 0.039). Polymorphisms in the gene may be associated with a higher risk of stable angina and ACS.
转录因子7样2（TCF7L2）是T细胞因子/淋巴样增强因子家族的关键成员，在人类生理过程中起关键作用，并与多种病理状况有关。TCF7L2与炎症、代谢调节以及动脉粥样硬化的发展相关。值得注意的是，TCF7L2通过激活特定分子途径发挥抗动脉粥样硬化作用。此外，基因多态性与冠状动脉疾病（CAD）的严重程度及相关死亡率有关。本研究旨在调查基因多态性rs77961654 A/C是否影响CAD风险。共纳入262例急性冠状动脉综合征（ACS）患者、313例稳定型心绞痛患者和488例健康个体。对rs77961654变体进行基因分型。与健康对照组相比，稳定型心绞痛组和ACS组中TCF7L2的CC基因型频率更高。在调整年龄、性别、收缩压、体重指数、空腹血糖、总胆固醇、甘油三酯和吸烟状况等混杂因素后，CC基因型与ACS和稳定型心绞痛的风险分别比AA基因型高10.46倍和8.00倍。此外，CC基因型与稳定型心绞痛和ACS均呈正相关，而AA基因型与ACS呈负相关。此外，与AA基因型患者相比，携带CC基因型的稳定型心绞痛或ACS患者的糖化血红蛋白、总白细胞计数和淋巴细胞计数水平显著升高，脂联素和分泌型卷曲相关蛋白5水平较低。还发现TCF7L2基因多态性与2型糖尿病之间存在显著关联（趋势p<0.039）。TCF7L2基因多态性可能与稳定型心绞痛和ACS的较高风险相关。
