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一种灭活新型三价疫苗可提供完全保护，抵御引起肝炎-心包积水综合征的禽腺病毒4型以及引起包涵体肝炎的禽腺病毒8b型/11型。

An Inactivated Novel Trivalent Vaccine Provides Complete Protection against FAdV-4 Causing Hepatitis-Hydropericardium Syndrome and FAdV-8b/-11 Causing Inclusion Body Hepatitis.

作者信息

Song Congcong, Zhao Shiyi, Song Mingzhen, Qiao Qilong, Yang Panpan, Wang Baiyu, Cong Yanfang, Wang Yanling, Liu Hongying, Wang Zeng, Wang Xinwei, Zhao Jun

机构信息

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.

National Animal Health Products for Engineering Technology Research Center, Qingdao 266111, China.

出版信息

Transbound Emerg Dis. 2023 Feb 22;2023:5122382. doi: 10.1155/2023/5122382. eCollection 2023.

DOI:10.1155/2023/5122382
PMID:40303753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12017159/
Abstract

Outbreaks of hepatitis-hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) and inclusion body hepatitis (IBH) related to FAdV-8b and FAdV-11 have been increased in chickens in China since 2015. Clinical concurrent infections of FAdV-4, FAdV-8b, and FAdV-11 are quite common, yet there are no commercially available trivalent vaccines against infection by these three serotypes. In our previous study, a bivalent vaccine based on a recombinant FAdV-4, of which -1 was replaced with the of FAdV-8b, has been developed. In this study, a novel recombinant rFAdV-4-fiber/8b + 11 was constructed by inserting FAdV-11 gene into the 1966-bp deletion region of rFAdV-4-fiber/8b genome. The replication ability of the rFAdV-4-fiber/8b + 11 was similar to the parental FAdV-4. One dose immunization with the inactivated rFAdV-4-fiber/8b + 11 vaccine generated robust immune responses against FAdV-4, FAdV-8b, and FAdV-11, and provided efficient clinical protection against FAdV-4, FAdV-8b, and FAdV-11 challenge. This study provides a novel strategy for developing potential trivalent vaccines for the prevention and control of HHS and IBH.

摘要

自2015年以来，由4型禽腺病毒（FAdV-4）引起的肝炎-心包积水综合征（HHS）以及与FAdV-8b和FAdV-11相关的包涵体肝炎（IBH）在中国鸡群中的暴发有所增加。FAdV-4、FAdV-8b和FAdV-11的临床合并感染相当常见，但目前尚无针对这三种血清型感染的商业化三价疫苗。在我们之前的研究中，已开发出一种基于重组FAdV-4的二价疫苗，其中FAdV-4的-1被FAdV-8b的 所取代。在本研究中，通过将FAdV-11 基因插入rFAdV-4-fiber/8b基因组的1966-bp缺失区域，构建了一种新型重组rFAdV-4-fiber/8b + 11。rFAdV-4-fiber/8b + 11的 复制能力与亲本FAdV-4相似。用灭活的rFAdV-4-fiber/8b + 11疫苗进行一次剂量免疫可产生针对FAdV-4、FAdV-8b和FAdV-11的强大免疫反应，并为抵抗FAdV-4、FAdV-8b和FAdV-11攻击提供有效的临床保护。本研究为开发预防和控制HHS和IBH的潜在三价疫苗提供了一种新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/f92a8f8fec0a/TBED2023-5122382.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/5270b00ae202/TBED2023-5122382.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/9a23879e3172/TBED2023-5122382.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/83a1e379e599/TBED2023-5122382.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/21a41711ce61/TBED2023-5122382.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/f92a8f8fec0a/TBED2023-5122382.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/5270b00ae202/TBED2023-5122382.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/e90b362ceeea/TBED2023-5122382.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/00fd98908fae/TBED2023-5122382.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/9a23879e3172/TBED2023-5122382.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/83a1e379e599/TBED2023-5122382.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/21a41711ce61/TBED2023-5122382.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ed/12017159/f92a8f8fec0a/TBED2023-5122382.007.jpg

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Probiotics Surface-Delivering Fiber2 Protein of Fowl Adenovirus 4 Stimulate Protective Immunity Against Hepatitis-Hydropericardium Syndrome in Chickens.益生菌表面递呈的禽腺病毒 4 纤维 2 蛋白可刺激鸡对肝炎-心包积水综合征的保护性免疫。
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Oral immunization of recombinant Saccharomyces cerevisiae expressing fiber-2 of fowl adenovirus serotype 4 induces protective immunity against homologous infection.
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Vet Microbiol. 2022 Aug;271:109490. doi: 10.1016/j.vetmic.2022.109490. Epub 2022 Jun 11.
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Advances in Vaccine Development of the Emerging Novel Genotype Fowl Adenovirus 4.新兴新型禽腺病毒 4 疫苗研发进展。
Front Immunol. 2022 May 20;13:916290. doi: 10.3389/fimmu.2022.916290. eCollection 2022.
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Epidemiological survey of avian adenovirus in China from 2015 to 2021 and the genetic variability of highly pathogenic Fadv-4 isolates.2015 年至 2021 年中国禽腺病毒的流行病学调查及高致病性 Fadv-4 分离株的遗传变异。
Infect Genet Evol. 2022 Jul;101:105277. doi: 10.1016/j.meegid.2022.105277. Epub 2022 Apr 1.
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