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A Bivalent Bacterium-like Particles-Based Vaccine Induced Potent Immune Responses against the Sudan Virus and Ebola Virus in Mice.

作者信息

Xu Shengnan, Li Wujian, Jiao Cuicui, Cao Zengguo, Wu Fangfang, Yan Feihu, Wang Hualei, Feng Na, Zhao Yongkun, Yang Songtao, Wang Jianzhong, Xia Xianzhu

机构信息

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China.

Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.

出版信息

Transbound Emerg Dis. 2023 Apr 24;2023:9248581. doi: 10.1155/2023/9248581. eCollection 2023.

DOI:10.1155/2023/9248581
PMID:40303775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12017122/
Abstract

Ebola virus disease (EVD) is an acute viral hemorrhagic fever disease causing thousands of deaths. The large Ebola outbreak in 2014-2016 posed significant threats to global public health, requiring the development of multiple medical measures for disease control. Sudan virus (SUDV) and Zaire virus (EBOV) are responsible for severe disease and occasional deadly outbreaks in West Africa and Middle Africa. This study shows that bivalent bacterium-like particles (BLPs)-based vaccine, SUDV-EBOV BLPs (S/ZBLP + 2 + P), generated by mixing SUDV-BLPs and EBOV-BLPs at a 1 : 1 ratio, is immunogenic in mice. The SUDV-EBOV BLPs induced potent immune responses against SUDV and EBOV and elicited both T-helper 1 (Th1) and T-helper 2 (Th2) immune responses. The results indicated that SUDV-EBOV BLPs-based vaccine has the potential to be a promising candidate against SUDV and EBOV infections and provide a strategy to develop universal vaccines for EVD.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/5f18c9a49ed5/TBED2023-9248581.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/befe7122a4fb/TBED2023-9248581.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/0019ce1228a3/TBED2023-9248581.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/d5360f34de36/TBED2023-9248581.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/4c47dd1b94d5/TBED2023-9248581.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/83d33350302f/TBED2023-9248581.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/bcbfd660b62f/TBED2023-9248581.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/5f18c9a49ed5/TBED2023-9248581.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/befe7122a4fb/TBED2023-9248581.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/0019ce1228a3/TBED2023-9248581.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/d5360f34de36/TBED2023-9248581.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/4c47dd1b94d5/TBED2023-9248581.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/83d33350302f/TBED2023-9248581.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/bcbfd660b62f/TBED2023-9248581.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7461/12017122/5f18c9a49ed5/TBED2023-9248581.007.jpg

相似文献

[1]
A Bivalent Bacterium-like Particles-Based Vaccine Induced Potent Immune Responses against the Sudan Virus and Ebola Virus in Mice.

Transbound Emerg Dis. 2023-4-24

[2]
Distinct Immunogenicity and Efficacy of Poxvirus-Based Vaccine Candidates against Ebola Virus Expressing GP and VP40 Proteins.

J Virol. 2018-5-14

[3]
A Bivalent, Spherical Virus-Like Particle Vaccine Enhances Breadth of Immune Responses against Pathogenic Ebola Viruses in Rhesus Macaques.

J Virol. 2020-4-16

[4]
Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses.

Front Immunol. 2021

[5]
Development of a cAdVax-based bivalent ebola virus vaccine that induces immune responses against both the Sudan and Zaire species of Ebola virus.

J Virol. 2006-3

[6]
A Chimeric Sudan Virus-Like Particle Vaccine Candidate Produced by a Recombinant Baculovirus System Induces Specific Immune Responses in Mice and Horses.

Viruses. 2020-1-3

[7]
A Novel Bacterium-Like Particle-Based Vaccine Displaying the SUDV Glycoprotein Induces Potent Humoral and Cellular Immune Responses in Mice.

Viruses. 2019-12-11

[8]
Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses.

PLoS One. 2015-9-30

[9]
Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease.

Nat Commun. 2025-5-6

[10]
Recombinant Modified Vaccinia Virus Ankara Generating Ebola Virus-Like Particles.

J Virol. 2017-5-12

本文引用的文献

[1]
A bacterium-like particle vaccine displaying Zika virus prM-E induces systemic immune responses in mice.

Transbound Emerg Dis. 2022-9

[2]
Bacterium-Like Particles Displaying the Rift Valley Fever Virus Gn Head Protein Induces Efficacious Immune Responses in Immunized Mice.

Front Microbiol. 2022-3-17

[3]
Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.

Cell. 2022-3-17

[4]
Human Antibodies for Viral Infections.

Annu Rev Immunol. 2022-4-26

[5]
Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development.

Front Immunol. 2021

[6]
Current state of Ebola virus vaccines: A snapshot.

PLoS Pathog. 2021-12-9

[7]
Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in healthy and HIV-infected adults: A randomised, placebo-controlled Phase II clinical trial in Africa.

PLoS Med. 2021-10

[8]
Review: Insights on Current FDA-Approved Monoclonal Antibodies Against Ebola Virus Infection.

Front Immunol. 2021

[9]
Modulation of immune response in Ebola virus disease.

Curr Opin Pharmacol. 2021-10

[10]
Genome structure and genetic diversity in the Ebola virus.

Curr Opin Pharmacol. 2021-10

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