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脊柱疾病治疗的创新方法:全面综述

Innovative Approaches for the Treatment of Spinal Disorders: A Comprehensive Review.

作者信息

Rostomian Edgmin, Ghookas Kevin, Postajian Alexander, Vartanian Kevin B, Hatamian Vedi, Fraix Marcel P, Agrawal Devendra K

机构信息

Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California 91766 USA.

出版信息

J Orthop Sports Med. 2025;7(1):144-161. doi: 10.26502/josm.511500190. Epub 2025 Mar 27.

DOI:10.26502/josm.511500190
PMID:40303932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040341/
Abstract

This comprehensive review explores the latest advancements in the management of spinal disorders, including minimally invasive surgical techniques, treatment of complex deformities, disc replacement technologies, and non-surgical approaches. The review highlights the potential of innovations such as robotic-assisted surgeries, regenerative medicine, and artificial intelligence to enhance precision, reduce recovery times, and improve patient outcomes. It also discusses the integration of wearable technologies and personalized medicine in tailoring treatments. Challenges such as high costs, accessibility issues, and limited long-term data are critically analyzed, alongside gaps in research, including a lack of diversity in study populations and insufficient economic evaluations. Future directions emphasize the need for multidisciplinary collaboration to develop durable, accessible, and personalized solutions to address the global burden of spinal disorders.

摘要

这篇综述探讨了脊柱疾病管理的最新进展,包括微创手术技术、复杂畸形的治疗、椎间盘置换技术和非手术方法。该综述强调了机器人辅助手术、再生医学和人工智能等创新技术在提高精准度、缩短恢复时间和改善患者预后方面的潜力。它还讨论了可穿戴技术和个性化医疗在定制治疗方案中的整合。对高成本、可及性问题和长期数据有限等挑战进行了批判性分析,同时也分析了研究中的差距,包括研究人群缺乏多样性和经济评估不足。未来的方向强调需要多学科合作,以开发持久、可及和个性化的解决方案,应对全球脊柱疾病负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c78/12040341/056c4d73d8aa/nihms-2072389-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c78/12040341/e9c4e0553404/nihms-2072389-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c78/12040341/056c4d73d8aa/nihms-2072389-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c78/12040341/e9c4e0553404/nihms-2072389-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c78/12040341/056c4d73d8aa/nihms-2072389-f0002.jpg

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本文引用的文献

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A Comparative Study of the Electroneurographic Findings in Amyloidotic Polyneuropathy in Patients with Light-Chain Amyloidosis and Glu54Gln Transthyretin Amyloidosis.轻链淀粉样变性和Glu54Gln转甲状腺素蛋白淀粉样变性患者淀粉样变性多发性神经病的神经电图结果比较研究
Medicina (Kaunas). 2024 Dec 9;60(12):2027. doi: 10.3390/medicina60122027.
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pH: A major player in degenerative intervertebral disks.pH值:退变椎间盘的一个主要因素。
JOR Spine. 2024 Dec 18;7(4):e70025. doi: 10.1002/jsp2.70025. eCollection 2024 Dec.
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Alginate vs. Hyaluronic Acid as Carriers for Nucleus Pulposus Cells: A Study on Regenerative Outcomes in Disc Degeneration.
藻酸盐与透明质酸作为髓核细胞载体的比较:椎间盘退变再生结果的研究
Cells. 2024 Nov 30;13(23):1984. doi: 10.3390/cells13231984.
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FOXG1 interaction with SATB2 promotes autophagy to alleviate neuroinflammation and mechanical abnormal pain in rats with lumbar disc herniation.FOXG1与SATB2的相互作用促进自噬,以减轻腰椎间盘突出症大鼠的神经炎症和机械性异常疼痛。
Ann Med. 2024 Dec;56(1):2399967. doi: 10.1080/07853890.2024.2399967. Epub 2024 Dec 3.
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Machine Learning Models Leveraging Smartphone-Based Patient Mobility Data Can Accurately Predict Functional Outcomes After Spine Surgery.利用基于智能手机的患者移动性数据的机器学习模型能够准确预测脊柱手术后的功能结果。
J Clin Med. 2024 Oct 30;13(21):6515. doi: 10.3390/jcm13216515.
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Molecular Imaging Biomarkers for Early Cancer Detection: A Systematic Review of Emerging Technologies and Clinical Applications.用于早期癌症检测的分子成像生物标志物:新兴技术与临床应用的系统评价
Diagnostics (Basel). 2024 Nov 3;14(21):2459. doi: 10.3390/diagnostics14212459.
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Long-term outcomes of spinal fusion in adolescent idiopathic scoliosis: a literature review.青少年特发性脊柱侧凸后路融合术的长期疗效:文献回顾。
Eur J Med Res. 2024 Nov 5;29(1):534. doi: 10.1186/s40001-024-02052-7.
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PLoS One. 2024 Oct 23;19(10):e0299415. doi: 10.1371/journal.pone.0299415. eCollection 2024.
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Discogenic Low Back Pain: Anatomic and Pathophysiologic Characterization, Clinical Evaluation, Biomarkers, AI, and Treatment Options.椎间盘源性下腰痛:解剖学和病理生理学特征、临床评估、生物标志物、人工智能及治疗选择
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