多序列磁共振成像及全肿瘤表观扩散系数直方图分析在鉴别p53异常与非p53异常子宫内膜癌中的价值

The value of multi-sequence magnetic resonance imaging and whole-tumor apparent diffusion coefficient histogram analysis in differentiating p53 abnormal from non-p53 abnormal endometrial carcinoma.

作者信息

Sun Yuying, Zhang Jieying, Wang Yilin, Zhang Xinxin, Chen Yan

机构信息

Radiology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Front Oncol. 2025 Apr 15;15:1565152. doi: 10.3389/fonc.2025.1565152. eCollection 2025.

DOI:10.3389/fonc.2025.1565152

PMID:40304002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12039310/

Abstract

OBJECTIVE

To investigate the utility of multi-sequence magnetic resonance imaging (MRI) and whole-tumor apparent diffusion coefficient (ADC) histogram metrics in preoperatively differentiating p53 abnormal (p53abn) from non-p53abn endometrial carcinoma (EC).

METHODS

This retrospective study included 146 EC patients (29 p53abn cases and 117 non-p53abn cases) who underwent preoperative MRI scans. MRI features were analyzed. Whole-tumor ADC histogram analysis was conducted by delineating regions of interest (ROIs) on diffusion-weighted imaging (DWI) scans. Receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC) was used for diagnostic performance evaluation.

RESULTS

Extrauterine extension (p=0.004) and lymphadenopathy (p=0.005) were more frequently observed in p53abn EC compared to non-p53abn EC. p53abn EC exhibited significantly lower value of minADC (p=0.001), meanADC (p=0.005), P10 (p=0.009), P50 (p=0.007), and P90 (p=0.013) ADC and higher value of kurtosis (p=0.008), compared to non-p53abn EC. MinADC demonstrated the highest discrimination ability in differentiating p53abn from non-p53abn EC [AUC 0.70(0.60;0.80)].

CONCLUSION

Preoperative multi-sequence MRI findings and whole-tumor ADC histogram metrics are conducive to differentiating p53abn from non-p53abn EC.

摘要

目的

探讨多序列磁共振成像（MRI）及全肿瘤表观扩散系数（ADC）直方图指标在术前鉴别p53异常（p53abn）与非p53abn子宫内膜癌（EC）中的应用价值。

方法

本回顾性研究纳入了146例术前行MRI扫描的EC患者（29例p53abn病例和117例非p53abn病例）。分析MRI特征。通过在扩散加权成像（DWI）扫描上勾画感兴趣区（ROI）进行全肿瘤ADC直方图分析。采用受试者操作特征（ROC）曲线分析及曲线下面积（AUC）评估诊断性能。

结果

与非p53abn EC相比，p53abn EC中子宫外扩展（p = 0.004）和淋巴结病（p = 0.005）更为常见。与非p53abn EC相比，p53abn EC的最小ADC（minADC）值（p = 0.001）、平均ADC（meanADC）值（p = 0.005）、第10百分位数（P10）（p = 0.009）、第50百分位数（P50）（p = 0.007）和第90百分位数（P90）ADC值显著更低，峰度值更高（p = 0.008）。MinADC在鉴别p53abn与非p53abn EC方面表现出最高的鉴别能力[AUC 0.70(0.60;0.80)]。