Sharp M L, McCurdy H D
J Am Vet Med Assoc. 1985 Aug 1;187(3):254-5.
Ninety-four dogs were randomly assigned to 1 of 6 groups (5 treated and 1 untreated control) for evaluation of anthelmintic efficacy. Three anthelmintic formulations were studied: a febantel paste, a praziquantel paste, and a combination paste containing both active ingredients. Treated dogs were dosed once daily for 3 days. The minimal effective dosages in combination were established as 10 mg of febantel and 1 mg of praziquantel/kg of body weight. At those dosages for the combination, 99.5% to 100% of the major nematodes and cestodes identified (ie, Ancylostoma caninum, Trichuris vulpis, Toxocara canis, Dipylidium caninum, and Taenia pisiformis) were eliminated. Febantel paste (10 mg/kg) alone was ineffective against cestodes (14.2% elimination of Dipylidium caninum) and praziquantel paste (1 mg/kg) alone was ineffective (0% to 2.4% elimination) against nematodes.
94只狗被随机分为6组中的1组（5个治疗组和1个未治疗对照组），以评估驱虫效果。研究了三种驱虫制剂：非班太尔糊剂、吡喹酮糊剂以及含有两种活性成分的联合糊剂。治疗组的狗每天给药1次，持续3天。联合用药的最小有效剂量确定为非班太尔10毫克和吡喹酮1毫克/千克体重。在这些联合用药剂量下，已鉴定出的主要线虫和绦虫（即犬钩口线虫、狐毛首线虫、犬弓首蛔虫、犬复孔绦虫和豆状带绦虫）有99.5%至100%被清除。单独使用非班太尔糊剂（10毫克/千克）对绦虫无效（犬复孔绦虫清除率为14.2%），单独使用吡喹酮糊剂（1毫克/千克）对线虫无效（清除率为0%至2.4%）。
