有患痴呆症风险的老年人的血液血管生成标志物与认知：有患痴呆症风险的老年人的血管生成血液标志物与认知
Blood Angiogenesis Markers and Cognition in Older Adults at Risk for Dementia: Marqueurs sanguins de l'angiogenèse et cognition chez les personnes âgées à risque de démence.
作者信息
Song Bing Xin, Vieira Erica, Gallagher Damien, Diniz Breno S, Fischer Corinne E, Flint Alastair J, Herrmann Nathan, Mah Linda, Mulsant Benoit H, Rajji Tarek K, Ma Clement, Lanctôt Krista L
机构信息
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada.
Geriatric Psychopharmacology Research Group, Sunnybrook Research Institute, Toronto, Ontario, Canada.
出版信息
Can J Psychiatry. 2025 Apr 30:7067437251337627. doi: 10.1177/07067437251337627.
ObjectiveChanges in angiogenesis have been shown to contribute to cognitive decline and dementia. We aimed to identify angiogenesis blood markers associated with cognitive performance in older adults with mild cognitive impairment (MCI), remitted major depressive disorder (rMDD), or both (rMDD + MCI) who are at risk for dementia.MethodWe analyzed data from participants with MCI, rMDD, or rMDD + MCI in the Prevention of Alzheimer's Dementia with Cognitive Remediation plus Transcranial Direct Current Stimulation in Mild Cognitive Impairment and Depression study. Elastic net regression was used to select variables associated with cognitive performance among 19 angiogenesis markers and 6 covariates. Linear regressions were used to determine which of the selected angiogenesis markers were associated with cognitive performance, controlling for the selected covariates. Significant angiogenesis markers were independently analyzed without other angiogenesis markers, controlling for covariates, with subgroup analyses in those with and without rMDD.ResultsAngiogenin was the only selected marker associated with cognitive performance ( = 0.28, = 0.03, ² = .02) when controlling for other selected markers (endothelial cell-specific molecule 1, e-selectin, interleukin-33 [IL-33], oncostatin M, platelet-derived growth factor-AB, IL-33 receptor, and tissue inhibitor of metalloproteinases-1) and selected covariates (age, education, apolipoprotein E ε4 status, diagnosis, and cardiovascular risk factors). When independently analyzed, angiogenin remained positively associated with cognitive performance ( = 0.21, = 0.01, ² =.02), controlling for the covariates. In subgroup analyses, angiogenin was also associated with cognition in rMDD and rMDD + MCI participants ( =0.50, SE = 0.14, < 0.001, ² = 0.08) and in MCI-only participants (= 0.20, SE = 0.09 = 0.02, ² = 0.02).ConclusionThe association of angiogenin with cognitive performance highlights a potentially novel biological pathway that could influence cognition in older adults at risk for dementia. Angiogenin may protect against cognitive decline, opening new avenues for innovative preventive, or therapeutic interventions.
目的
血管生成的变化已被证明与认知能力下降和痴呆症有关。我们旨在确定与轻度认知障碍（MCI）、缓解期重度抑郁症（rMDD）或两者兼具（rMDD + MCI）且有患痴呆症风险的老年人认知表现相关的血管生成血液标志物。
方法
我们分析了“轻度认知障碍和抑郁症认知修复加经颅直流电刺激预防阿尔茨海默病痴呆症”研究中MCI、rMDD或rMDD + MCI参与者的数据。弹性网回归用于在19种血管生成标志物和6个协变量中选择与认知表现相关的变量。线性回归用于确定所选血管生成标志物中哪些与认知表现相关，并对所选协变量进行控制。对显著的血管生成标志物在不考虑其他血管生成标志物的情况下进行独立分析，并对协变量进行控制，同时对有和没有rMDD的参与者进行亚组分析。
结果
在控制其他所选标志物（内皮细胞特异性分子1、e - 选择素、白细胞介素 - 33 [IL - 33]、抑瘤素M、血小板衍生生长因子 - AB、IL - 33受体和金属蛋白酶组织抑制剂 - 1）和所选协变量（年龄、教育程度、载脂蛋白E ε4状态、诊断和心血管危险因素）时，血管生成素是唯一与认知表现相关的所选标志物（β = 0.28，P = 0.03，R² = 0.02）。在独立分析时，血管生成素在控制协变量的情况下仍与认知表现呈正相关（β = 0.21，P = 0.01，R² = 0.02）。在亚组分析中，血管生成素在rMDD和rMDD + MCI参与者（β = 0.50，标准误 = 0.14，P < 0.001，R² = 0.08）以及仅患有MCI的参与者（β = 0.20，标准误 = 0.09，P = 0.02，R² = 0.02）中也与认知相关。
结论
血管生成素与认知表现的关联突出了一条潜在的新生物学途径，该途径可能影响有患痴呆症风险的老年人的认知。血管生成素可能预防认知能力下降，为创新的预防或治疗干预开辟了新途径。
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