Shulkin Aaron, Abid Naushad, Rasheed Mehmoodur
Carle Illinois College of Medicine, University of Illinois Urbana-Champaign.
College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
ACR Open Rheumatol. 2025 May;7(5):e70050. doi: 10.1002/acr2.70050.
Seropositive rheumatoid arthritis (RA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) are two autoimmune conditions with unique etiologies and clinical presentations. Although few reports have documented rare cases in which a single individual has both conditions at the same time, it is much rarer to see them in sequence of each other. Here, we report a 69-year-old man diagnosed with AAV before achieving remission following six years of treatment. Following two years of remission, he was subsequently diagnosed with seropositive RA. This case invites unique insights to further explore underlying etiologies of autoimmune diseases and the interrelationship between them.
血清阳性类风湿性关节炎(RA)和抗中性粒细胞胞浆抗体相关性血管炎(AAV)是两种病因和临床表现独特的自身免疫性疾病。虽然很少有报告记录单个个体同时患有这两种疾病的罕见病例,但先后出现这两种疾病的情况更为罕见。在此,我们报告一名69岁男性,在接受六年治疗后病情缓解前被诊断为AAV。病情缓解两年后,他随后被诊断为血清阳性RA。该病例为进一步探索自身免疫性疾病的潜在病因及其相互关系提供了独特的见解。