Gulack Brian C, Kwong Jacky, Sullivan Gwyneth, Ritz Ethan, Kesavan Anil A, Shah Ami N
Division of Pediatric Surgery, Department of Surgery, Rush University Medical Center, 1725 West Harrison Street, Professional Building Suite 710, Chicago, IL, 60612, USA.
Department of General Surgery, Rush University Medical Center, 1653 W. Congress Parkway, Chicago, IL, 60612, USA.
Pediatr Surg Int. 2025 Apr 30;41(1):127. doi: 10.1007/s00383-025-06031-9.
Super absorbent polymer (SAP) beads grow in the presence of liquids, leading to a risk of small bowel obstruction (SBO) following ingestion, but there is little data to guide management in children following SAP bead ingestion. We hypothesize that certain hypertonic liquids could limit the growth of the beads and shrink them, potentially serving as a treatment to prevent SBO.
Specific hypertonic liquids were identified a priori to be studied including 100% fruit juices, mineral oil, 50% and 100% Gastrografin, Pedialyte, Cola, polyethylene glycol, and Milk of Magnesia. Simulated intestinal fluid was used as a control. SAP bead growth and shrinkage (after 24 h of pre-hydration) were compared using linear regression with log transformation.
Mineral oil, Gastrografin, and 100% fruit juices were found to be the most effective at preventing bead growth as compared to intestinal fluid for both small and large beads (p < 0.001). 100% fruit juices were found to be the most effective at shrinking pre-hydrated beads (p < 0.001).
Gastrografin and 100% fruit juices have the potential to limit the growth of and shrink SAP beads following ingestion. Protocols using these liquids following SAP bead ingestion may be beneficial in preventing SBO-related surgery.
高吸水性聚合物（SAP）珠粒在液体存在的情况下会生长，导致摄入后有发生小肠梗阻（SBO）的风险，但关于儿童摄入SAP珠粒后的管理，几乎没有数据可供指导。我们假设某些高渗液体可以限制珠粒的生长并使其收缩，有可能作为预防SBO的一种治疗方法。
预先确定要研究的特定高渗液体，包括100%果汁、矿物油、50%和100%泛影葡胺、口服补液盐、可乐、聚乙二醇和氢氧化镁乳剂。使用模拟肠液作为对照。通过对数转换后的线性回归比较SAP珠粒的生长和收缩情况（预水化24小时后）。
与肠液相比，发现矿物油、泛影葡胺和100%果汁对防止小珠粒和大珠粒的生长最有效（p<0.001）。发现100%果汁对收缩预水化珠粒最有效（p<0.001）。
泛影葡胺和100%果汁有可能限制摄入后SAP珠粒的生长并使其收缩。在摄入SAP珠粒后使用这些液体的方案可能有助于预防与SBO相关的手术。
