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Quercetin and Cardiac Fibrosis-Promise or Polyphenolic Placebo?

作者信息

Birnbaum Yochai, Connely Kim

机构信息

The Department of Medicine, Section of Cardiology, Baylor College of Medicine, 7200 Cambridge Street, MS BCM620, Houston, TX, 7730, USA.

Cardiology St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

出版信息

Cardiovasc Drugs Ther. 2025 Apr 30. doi: 10.1007/s10557-025-07705-1.

DOI:10.1007/s10557-025-07705-1
PMID:40304960
Abstract
摘要

相似文献

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Quercetin and Cardiac Fibrosis-Promise or Polyphenolic Placebo?槲皮素与心脏纤维化——前景还是多酚安慰剂？
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2
Quercetin Alleviates Cardiac Fibrosis via Regulating the SIRT3 Signaling Pathway.槲皮素通过调节SIRT3信号通路减轻心脏纤维化。
Cardiovasc Drugs Ther. 2024 Dec 16. doi: 10.1007/s10557-024-07658-x.
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The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta-analysis.槲皮素治疗肝纤维化的临床前证据构建：系统评价和荟萃分析。
Phytother Res. 2022 Oct;36(10):3774-3791. doi: 10.1002/ptr.7569. Epub 2022 Aug 2.
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Quercetin targets TGFβ-primed human MDA-MB-231 triple-negative breast cancer cells, linking epithelial-mesenchymal transition to cell senescence and fibrosis.槲皮素作用于经转化生长因子β（TGFβ）预处理的人MDA - MB - 231三阴性乳腺癌细胞，将上皮-间质转化与细胞衰老和纤维化联系起来。
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An intricate role of Ang II/AT1 in the modulation of monosodium glutamate-induced pulmonary fibrosis by TGF-β/Smad through quercetin.血管紧张素II/1型血管紧张素受体在槲皮素通过转化生长因子-β/信号转导和转录激活因子对味精诱导的肺纤维化的调节中所起的复杂作用。
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A detailed overview of quercetin: implications for cell death and liver fibrosis mechanisms.槲皮素的详细概述：对细胞死亡和肝纤维化机制的影响
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Quercetin provides greater cardioprotective effect than its glycoside derivative rutin on isoproterenol-induced cardiac fibrosis in the rat.槲皮素对异丙肾上腺素诱导的大鼠心肌纤维化的心脏保护作用强于其糖苷衍生物芦丁。
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Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation.载脂蛋白E缺陷小鼠饮用红酒、或摄入其多酚类物质槲皮素或儿茶素后，动脉粥样硬化进展减缓，这与低密度脂蛋白氧化和聚集易感性降低有关。
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2744-52. doi: 10.1161/01.atv.17.11.2744.

本文引用的文献

1
Quercetin Alleviates Cardiac Fibrosis via Regulating the SIRT3 Signaling Pathway.槲皮素通过调节SIRT3信号通路减轻心脏纤维化。
Cardiovasc Drugs Ther. 2024 Dec 16. doi: 10.1007/s10557-024-07658-x.
2
Research progress of quercetin in cardiovascular disease.槲皮素在心血管疾病中的研究进展
Front Cardiovasc Med. 2023 Nov 16;10:1203713. doi: 10.3389/fcvm.2023.1203713. eCollection 2023.
3
Quercetin Attenuates Cardiac Hypertrophy by Inhibiting Mitochondrial Dysfunction Through SIRT3/PARP-1 Pathway.槲皮素通过SIRT3/PARP-1途径抑制线粒体功能障碍减轻心脏肥大。
Front Pharmacol. 2021 Oct 28;12:739615. doi: 10.3389/fphar.2021.739615. eCollection 2021.
4
Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3.槲皮素通过调节 miR-223-3p/FOXO3 促进自噬来预防异丙肾上腺素诱导的心肌纤维化。
Cell Cycle. 2021 Jul;20(13):1253-1269. doi: 10.1080/15384101.2021.1932029. Epub 2021 Jun 7.
5
Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis.槲皮素逆转高脂饮食喂养小鼠的心脏收缩功能障碍：血管生成的作用。
Oxid Med Cell Longev. 2021 Feb 19;2021:8875729. doi: 10.1155/2021/8875729. eCollection 2021.
6
Quercetin Dihydrate inhibition of cardiac fibrosis induced by angiotensin II in vivo and in vitro.槲皮素二水合物对血管紧张素Ⅱ诱导的体内外心肌纤维化的抑制作用。
Biomed Pharmacother. 2020 Jul;127:110205. doi: 10.1016/j.biopha.2020.110205. Epub 2020 May 8.
7
Quercetin provides greater cardioprotective effect than its glycoside derivative rutin on isoproterenol-induced cardiac fibrosis in the rat.槲皮素对异丙肾上腺素诱导的大鼠心肌纤维化的心脏保护作用强于其糖苷衍生物芦丁。
Can J Physiol Pharmacol. 2013 Nov;91(11):951-9. doi: 10.1139/cjpp-2012-0432. Epub 2013 Jul 13.
8
Quercetin inhibits left ventricular hypertrophy in spontaneously hypertensive rats and inhibits angiotensin II-induced H9C2 cells hypertrophy by enhancing PPAR-γ expression and suppressing AP-1 activity.槲皮素通过增强 PPAR-γ 表达和抑制 AP-1 活性抑制自发性高血压大鼠左心室肥厚，并抑制血管紧张素 II 诱导的 H9C2 细胞肥大。
PLoS One. 2013 Sep 10;8(9):e72548. doi: 10.1371/journal.pone.0072548. eCollection 2013.
9
Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension.槲皮素可恢复肾血管性高血压患者的血浆亚硝酸盐和亚硝基物质水平。
Naunyn Schmiedebergs Arch Pharmacol. 2010 Oct;382(4):293-301. doi: 10.1007/s00210-010-0546-1. Epub 2010 Aug 8.