Liang Zhao, Ali Qurban, Wu Huijun, Gu Qin, Liu Xin, Sun Houjun, Gao Xuewen
The Sanya Institute, Nanjing Agricultural University, Sanya 572024, China.
Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China.
Biomolecules. 2025 Apr 1;15(4):519. doi: 10.3390/biom15040519.
() is widely recognized as the most important microbial pesticide controlling various insect pests and diseases due to its insecticidal crystal proteins (ICPs) and antimicrobial metabolites. The current study investigates the biocontrol potential of GBAC46 against the fungal pathogen and the insect pest through multiple mechanisms. Phenotypic experiments revealed that GBAC46 effectively inhibited growth by inducing reactive oxygen species (ROS) accumulation and showed enhanced larvicidal activity against second instar larvae. Pot experiments showed that feeding by enhanced infection in maize. The strain GBAC46 effectively controlled both pests and diseases in greenhouse maize seedlings. Applying the strain GBAC46 reduced feeding damage from , decreased leaf yellowing and wilting caused by , and improved growth indicators such as plant height, fresh weight, and dry weight. RT-qPCR results revealed that the strain GBAC46 induced key defense genes in maize involved in activating salicylic acid, jasmonic acid, and ethylene pathways. The overall study demonstrated and confirmed the GBAC46 strain as a promising microbial agent for disease and pest management.
由于其杀虫晶体蛋白（ICPs）和抗菌代谢产物，（）被广泛认为是控制各种病虫害的最重要的微生物杀虫剂。目前的研究通过多种机制研究了GBAC46对真菌病原体和害虫的生物防治潜力。表型实验表明，GBAC46通过诱导活性氧（ROS）积累有效抑制了（）的生长，并对二龄（）幼虫表现出增强的杀幼虫活性。盆栽实验表明，（）取食增强了玉米中（）的感染。GBAC46菌株有效地控制了温室玉米幼苗中的病虫害。施用GBAC46菌株减少了（）的取食危害，减少了由（）引起的叶片发黄和枯萎，并改善了株高、鲜重和干重等生长指标。RT-qPCR结果表明，GBAC46菌株诱导了玉米中参与激活水杨酸、茉莉酸和乙烯途径的关键防御基因。总体研究证明并确认GBAC46菌株是一种有前途的用于病虫害管理的微生物制剂。
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