Lee L Y, Morton R F, Frazier D T
J Appl Physiol (1985). 1985 Jul;59(1):229-36. doi: 10.1152/jappl.1985.59.1.229.
To determine whether the acute ventilatory responses to inhaled cigarette smoke are affected by a difference in nicotine level, control cigarettes (low-nicotine research cigarettes) were laced with nicotine to generate an increase of 330% (mean) in nicotine content with little or no change in the levels of other smoke constituents. Acute ventilatory responses to both control and nicotine-laced cigarettes were determined and compared in six awake chronic dogs. Spontaneous inhalation of nicotine-laced cigarette smoke (10% concn, 750 ml vol) via a tracheostomy tube caused distinct and consistent changes in breathing pattern on the first or second breath of inhaled smoke: an apnea in three dogs, an augmented inspiration in two dogs, and rapid shallow breathing in one dog. No significant change in breathing pattern was found immediately following inhalation of control cigarette smoke. Both types of cigarettes caused a delayed hyperpnea. However, the increase in minute ventilation induced by nicotine-laced cigarettes (from a base line of 2.8 to a peak of 25.7 l/min) was significantly greater than that by control cigarettes (from 2.9 to 5.5 l/min). Results of this study suggest that nicotine is responsible for the elicitation of both the immediate and delayed ventilatory responses to inhaled cigarette smoke generated under our experimental conditions.
为了确定吸入香烟烟雾后的急性通气反应是否受尼古丁水平差异的影响，将对照香烟（低尼古丁研究香烟）添加尼古丁，使尼古丁含量平均增加330%，而其他烟雾成分水平几乎没有变化或没有变化。在6只清醒的慢性犬中测定并比较了对对照香烟和添加尼古丁香烟的急性通气反应。通过气管造口管自主吸入添加尼古丁的香烟烟雾（浓度10%，体积750毫升），在吸入烟雾的第一口或第二口时，呼吸模式出现明显且一致的变化：3只犬出现呼吸暂停，2只犬吸气增强，1只犬出现快速浅呼吸。吸入对照香烟烟雾后，呼吸模式没有立即出现显著变化。两种香烟均导致延迟性呼吸急促。然而，添加尼古丁香烟引起的分钟通气量增加（从基线的2.8升/分钟增加到峰值25.7升/分钟）显著大于对照香烟（从2.9升/分钟增加到5.5升/分钟）。本研究结果表明，在我们的实验条件下，尼古丁是引发吸入香烟烟雾后立即和延迟通气反应的原因。
